Results 61 to 70 of about 886,427 (297)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Comparative study between oral and intralesional injection of beta-blocker in the treatment of infantile capillary hemangioma

Egyptian Pediatric Association Gazette
Purpose The present is conducted with the aim of comparing the clinical efficacy and side effects of oral versus intralesional propranolol treatment of infantile capillary hemangiomas.
Sahar S Sheta, Kareem B. Elessawy, Nadeen Eltoukhy, Ayman Esmail, Walaa ElNaggar   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Beta-Blocker Type Effect on Substrate Oxidation during HIIE in Heart Failure Patients: Pilot Data

, 2019
The effect of third and second-generation type of beta-blocker on substrate oxidation especially during high-intensity exercises are scarce. The objective of the study is to explore differences of beta-blocker regimens (vasodilating vs.
Anil Nigam (2621785), Martin Juneau (2621791), Philippe Meyer (271794), Paula Aver Bretanha Ribeiro (6515885), Michel White (303419), Eve Normandin (6515888), Mathieu Gayda (2621803)   +6 more
core   +1 more source

Randomized Evaluation of Beta Blocker and ACE-Inhibitor/Angiotensin Receptor Blocker Treatment for Post Infarct Angina in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries : A MINOCA-BAT Sub Study Rationale and Design

, 2021
Introduction: Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in ~10% of all patients with acute myocardial infarction (AMI), with an over-representation amongst women.
Tavella, Rosanna,, Beltrame, John F, Rajwani, Adil,, Mooney, John, Singh, Kuljit, Nordenskjöld, Anna M., Arstall, Margaret, Worthley, Matthew, Nordenskjöld, Anna M.,, Singh, Kuljit,, Zeitz, Christopher,, Tavella, Rosanna, Arstall, Margaret,, Beltrame, John F., Nordenskjold, Anna M, Neil, Christopher,, Neil, Christopher, Lindahl, Bertil, Pasupathy, Sivabaskari,, Rajwani, Adil, Turner, Stuart,, Lindahl, Bertil,, Zeitz, Christopher, Mooney, John,, Pasupathy, Sivabaskari, Worthley, Matthew,, Beltrame, John F.,, Turner, Stuart   +27 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Meta-analysis of the benefit of beta-blockers for the reduction of isolated atrial fibrillation incidence after cardiac surgeryCentral MessagePerspective

JTCVS Open, 2020
Objectives: Postoperative atrial fibrillation (POAF) is a common problem of cardiac surgery. Beta-blockers are recognized as effective prophylactic agents available for POAF management.
Yoshio Masuda, MBBS, Hai Dong Luo, MD, PhD, Giap Swee Kang, MBBS, FRCS, Kristine Leok-Kheng Teoh, MBBS, FRCS, Theodoros Kofidis, MD, FRCS   +4 more
doaj   +1 more source

Fred A. Blocker with Bully

, 1940
This is a black and white photograph of Fred A. Blocker with Bully. Here, Bully is the live school mascot, and he is an English Bulldog. Bully and Blocker are seated on a platform outside a relatively large, enclosed dog house structure.
Blocker, Fred A.
core  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source