Results 41 to 50 of about 886,427 (297)

Use of beta-blockers and risk of serious upper gastrointestinal bleeding: a population-based case-control study

Therapeutic Advances in Gastroenterology, 2017
Background: Some studies indicate a reduced risk of serious upper gastrointestinal bleeding (UGIB) for users of beta-blockers, but the association remains to be confirmed in larger studies and characterized with respect to differences among beta-blockers.
Mette Reilev, Per Damkier, Lotte Rasmussen, Morten Olesen, Martin Thomsen Ernst, Rikke Mie Rishøj, Morten Rix Hansen, Anne Broe, Alexander Steenberg Dastrup, Maja Hellfritzsch, Sidsel Arnspang, Anton Pottegård, Jesper Hallas   +12 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The effect of beta blockers on heart rate response during the Chester Step Test [PDF]

, 2011
The objective of this study is to ascertain that as the intensity of exercise increases through the stages of the Chester Step Test (CST) does the difference between the beta blocked(BB) and the non beta blocked(NBB) participants heart rate(HR) response ...
Gilchrest, Joanne
core   +2 more sources

GAMBARAN PERESEPAN OBAT BETA BLOCKER PADA PASIEN GAGAL JANTUNG SISTOLIK YANG DIRAWAT JALAN DI RSUP DR. KARIADI SEMARANG

Jurnal Kedokteran Diponegoro, 2018
Latar Belakang: Gagal jantung sistolik merupakan kegagalan jantung untuk memberikan suplai darah dalam memenuhi kebutuhan metabolisme jaringan dengan hipertrofi dinding ventrikel yang memiliki output terbatas karena ejeksi yang terganggu selama sistol ...
Monica Destiani, Ilham Uddin, Pipin Ardhianto   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Influence of Beta Blockers on Survival in Dogs with Severe Subaortic Stenosis

Journal of Veterinary Internal Medicine, 2014
Background Subaortic stenosis (SAS) is one of the most common congenital cardiac defects in dogs. Severe SAS frequently is treated with a beta adrenergic receptor blocker (beta blocker), but this approach largely is empirical.
B.D. Eason, D.M. Fine, D. Leeder, C. Stauthammer, K. Lamb, A.H. Tobias   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Maternal beta‐blocker dose and risk of small‐for gestational‐age in women with heart disease

Acta Obstetricia et Gynecologica Scandinavica, 2022
Introduction Beta‐blockers are prescribed for many pregnant women with heart disease, but whether there is a dose‐dependent effect on fetal growth remains to be examined. We aimed to investigate if antenatal beta‐blocker use and dose were associated with
Ingvil Krarup Sørbye, Randi Haualand, Henriette Wiull, Anne‐Sofie Letting, Eldrid Langesæter, Mette‐Elise Estensen   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source