Results 71 to 80 of about 125,081 (292)

Physical Activity, Sedentary Time and Physical Capability in Early Old Age: British Birth Cohort Study [PDF]

, 2015
Purpose To investigate the associations of time spent sedentary, in moderate-to-vigorous-intensity physical activity (MVPA) and physical activity energy expenditure (PAEE) with physical capability measures at age 60-64 years.
Abington, J, Adams, JE, Ambrosini, G, Boardman, K, Bonar, K, Brage, S, Bruce, I, Bryant, S, Chapman, A, Chaturvedi, N, Cheshire, H, Chowienczyk, P, Clements, G, Clements, R, Cole, D, Cooper, AJM, Cooper, R, Crabtree, N, Craig, K, Darroch, P, Deanfield, J, Demetrescu, C, Donald, A, Edwards, J, Ekelund, U, Ell, P, Evans, W, Franklyn, J, Fraser, A, Friberg, P, Ghosh, A, Hannan, J, Hardy, R, Harris, J, Harwood, N, Howard, E, Hughes, A, Inglis, L, Jiang, B, Khattar, RS, Kok, S, Kuh, D, Lessof, C, MacAllister, R, Macfarlane, P, Machin, M, March, K, Marshall, F, Masi, S, Mayle, S, McNeill, K, Miller, C, Morley, T, Nair, SB, Newby, D, Nip, W, Osika, W, Oughton, E, Palmer, S, Pellerin, D, Petit, R, Phalora, R, Pierce, M, Reece, E, Richards, M, Scanlon, M, Simmons, RK, Singzon, R, Spector, T, Steeds, R, Stephens, AM, Suvari, M, Townsend, C, Westgate, K, White, A, Wong, A, Woodside, J   +76 more
core   +12 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Meta-analysis of the benefit of beta-blockers for the reduction of isolated atrial fibrillation incidence after cardiac surgeryCentral MessagePerspective

JTCVS Open, 2020
Objectives: Postoperative atrial fibrillation (POAF) is a common problem of cardiac surgery. Beta-blockers are recognized as effective prophylactic agents available for POAF management.
Yoshio Masuda, MBBS, Hai Dong Luo, MD, PhD, Giap Swee Kang, MBBS, FRCS, Kristine Leok-Kheng Teoh, MBBS, FRCS, Theodoros Kofidis, MD, FRCS   +4 more
doaj   +1 more source

Flowers Hospital: Nearing Perfection on Core Measures [PDF]

, 2008
Describes elements of a strategy for achieving high process-of-care performance by continuously monitoring patients in four clinical areas and ensuring they receive the right care -- including concurrent reviews and quality improvement ...
Jennifer N. Edwards
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effects of sacubitril/valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) according to background therapy [PDF]

, 2016
Background—In the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the ...
Gong, Jianjian, Jhund, Pardeep S., Lefkowitz, Martin P., McMurray, John J.V., Okumura, Naoki, Packer, Milton, Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R.   +11 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Which patients undergoing noncardiac surgery benefit from perioperative beta-blockers? [PDF]

, 2008
Patients with moderate to high cardiac risk (a Revised Cardiac Risk Index [RCRI] score of 2 or higher [Table]) have a reduced risk of in-hospital death following perioperative beta-blocker therapy (strength of recommendation [SOR]: B, based on a large ...
Haynes, Jamie, Jamieson, Barbara, Kelsberg, Gary   +2 more
core  

Prophylactic use of carvedilol to prevent ventricular dysfunction in patients with cancer treated with doxorubicin [PDF]

, 2018
Objective: Deterioration in ventricular function is often observed in patients treated with anthracyclines for cancer. There is a paucity of evidence on interventions that might provide cardio-protection.
Abrar, Mohammed Burhan, Abuosa, Ahmed Mohamed, Ahmed, Adel H., Andejani, Abdulwahab, Cleland, John G.F., Elshiekh, Ayman Hassan, Kholeif, Mona A., Kinsara, Abdulhalim Jamal, Qureshi, Kahekashan   +8 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source