Results 41 to 50 of about 187,919 (323)

Prophylactic use of carvedilol to prevent ventricular dysfunction in patients with cancer treated with doxorubicin [PDF]

, 2018
Objective: Deterioration in ventricular function is often observed in patients treated with anthracyclines for cancer. There is a paucity of evidence on interventions that might provide cardio-protection.
Abrar, Mohammed Burhan, Abuosa, Ahmed Mohamed, Ahmed, Adel H., Andejani, Abdulwahab, Cleland, John G.F., Elshiekh, Ayman Hassan, Kholeif, Mona A., Kinsara, Abdulhalim Jamal, Qureshi, Kahekashan   +8 more
core   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Use of Beta-Blockers as a First-Line Treatment for Primary Hypertension

Hearts
Background: Even though beta-blockers had been used as a first-line therapy for hypertension, since the late 1960s, the Eighth Joint National Committee, JNC 8, decided to recommend them no longer.
Maryam Izadi, Shiva Shafabakhsh, Amir Mirnateghi   +2 more
doaj   +1 more source

Self-reported and actual beta-blocker prescribing for heart failure patients: physician predictors.

PLoS ONE, 2009
BackgroundBeta-blockers reduce mortality among patients with systolic heart failure (HF), yet primary care provider prescription rates remain low.ObjectiveTo examine the association between primary care physician characteristics and both self-reported ...
Sanjai Sinha, Mark D Schwartz, Angie Qin, Joseph S Ross   +3 more
doaj   +1 more source

Beta-blockers in chronic heart failure with preserved left ventricular ejection fraction: is deprescribing possible?

Рациональная фармакотерапия в кардиологии, 2023
Chronic heart failure (CHF) is a complex clinical syndrome characterized by poor prognosis. According to the Russian epidemiological study EPOHA-CHF, more than half of patients with CHF have preserved left ventricular ejection fraction (LV EF).
V. D. Zakiev, N. M. Vorobyeva, I. P. Malaya, A. D. Gvozdeva, O. N. Tkacheva   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Beta-adrenergic blocking agents in cutaneous and oral melanoma

Oral Oncology Reports
Beta-adrenergic blocking agents, or beta-blockers, are primarily used to manage cardiovascular conditions such as hypertension, heart failure, and arrhythmias by blocking the effects of stress hormones on beta-adrenergic receptors, reducing heart rate ...
Sivakamavalli Jeyachandran
doaj   +1 more source

Hemodynamic Evaluation of Nonselective \u3b2-Blockers in Patients with Cirrhosis and Refractory Ascites [PDF]

, 2018
BACKGROUND:Nonselective \u3b2-blockers (NSBB) have been associated with increased incidence of paracentesis-induced circulatory dysfunction (PICD) and reduced survival in patients with cirrhosis and refractory ascites.
Angeli, Paolo, Burra, Patrizia, Casiglia, Edoardo, Faggian, Diego, Fasolato, Silvano, Ferrarese, Alberto, Germani, Giacomo, Russo, Francesco Paolo, Senzolo, Marco, Tikhonoff, Valerie, Zanetto, Alberto   +10 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source