Results 41 to 50 of about 908,735 (292)

Beta Blockers and Melanoma

Open Access Macedonian Journal of Medical Sciences, 2019
Understanding the mechanisms of cancer immune-tolerance is one of the most important challenges. Several studies have demonstrated the potential anticarcinogenic effects of beta-blockers, in patients with prostate cancer, breast cancer, and melanoma.
Vojvodic, Aleksandra, Vojvodic, Petar, Vlaskovic-Jovicevic, Tatjana, Sijan, Goran, Dimitrijevic, Sanja, Peric-Hajzler, Zorica, Matovic, Dusica, Wollina, Uwe, Tirant, Michael, Thuong, Nguyen Van, Fioranelli, Massimo, Lotti, Torello   +11 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Impact of renal impairment on beta-blocker efficacy in patients with heart failure [PDF]

, 2019
14 p.The Beta-Blockers in Heart Failure Collaborative Group (Collaborative Systematic Overview of Randomised Controlled Trials of Beta-Blockers in the Treatment of Heart Failure [BB-meta-HF])Background: Moderate and moderately severe renal impairment are
Manzano Espinosa, Luis, Ruschitzka, Frank, Coats, Andrew J.S., Holmes, Jane, Redon, Josep, Von Lueder, Thomas G., McMurray, John J.V., Van Veldhuisen, Dirk J., Damman, Kevin, Anker, Stefan D., Wedel, Hans, Gill, Simrat K., Cleland, John G.F., Flather, Marcus D., Kjekshus, John, Packer, Milton, Wikstrand, John, Böhm, Michael, Rosano, Giuseppe, Kotecha, Dipak, Andersson, Bert, Rigby, Alan S.   +21 more
core   +1 more source

Beta-adrenergic blocking agents in cutaneous and oral melanoma

Oral Oncology Reports
Beta-adrenergic blocking agents, or beta-blockers, are primarily used to manage cardiovascular conditions such as hypertension, heart failure, and arrhythmias by blocking the effects of stress hormones on beta-adrenergic receptors, reducing heart rate ...
Sivakamavalli Jeyachandran
doaj   +1 more source

Beta-blockers in chronic heart failure with preserved left ventricular ejection fraction: is deprescribing possible?

Рациональная фармакотерапия в кардиологии, 2023
Chronic heart failure (CHF) is a complex clinical syndrome characterized by poor prognosis. According to the Russian epidemiological study EPOHA-CHF, more than half of patients with CHF have preserved left ventricular ejection fraction (LV EF).
V. D. Zakiev, N. M. Vorobyeva, I. P. Malaya, A. D. Gvozdeva, O. N. Tkacheva   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Beta-blockers: friend or foe in asthma?

, 2013
Bente Arboe, Charlotte Suppli UlrikDepartment of Pulmonary Medicine, Hvidovre Hospital and University of Copenhagen, Hvidovre, DenmarkBackground and aim: Recently, β-blockers have been suggested as a potential maintenance treatment option for asthma.
Arboe, Bente, Ulrik CS, Ulrik, Charlotte Suppli, Arboe B   +3 more
core   +1 more source

Long-term benefit of vasodilating beta-blockers in acute myocardial infarction patients with mildly reduced left ventricular ejection fraction.

PLoS ONE
Beta-blockers have been considered the cornerstone of treatment for patients with acute myocardial infarction (AMI). However, long-term benefits of vasodilating beta-blockers remain uncertain.
Ki Yung Boo, Miyeon Kim, Jae-Geun Lee, Geum Ko, Joon Hyouk Choi, Song-Yi Kim, Seung-Jae Joo, Jin-Yong Hwang, Seung-Ho Hur, Kwang Soo Cha, Myung Ho Jeong, KAMIR-NIH registry investigators   +11 more
doaj   +1 more source