Results 71 to 80 of about 908,735 (292)
Neurobiology of Disease, 2020 Adrenergic systems regulate both cognitive function and immune function. The primary source of adrenergic signaling in the brain is norepinephrine (NE) neurons of the locus coeruleus (LC), which are vulnerable to age-related degeneration and are one of ...
Andrew K. Evans +5 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The Pharmacology of Beta blockers and Ivabradine
, 2019 The β-adrenoceptor antagonists also known as beta blockers are an important group of drugs. They were first discovered in 1958, 10 years after Ahlquist had postulated the existence of β-adrenoceptors.
Lee, DongHwa
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Beta- Blockers and Dental patient
, 2016 Beta-blockers are important group of drugs that is particularly used for treatment, prevention and management of the cardiovascular diseases. Determination and controlling these patients who visit the dental clinic are given significant information to ...
Kim Tu, Nguyen Bat
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Current Knowledge of Beta-Blockers in Chronic Hemodialysis Patients
International Journal of Nephrology and Renovascular Disease, 2023 Intissar Haddiya,1,2 Siria Valoti3 1Department of Nephrology, Faculty of Medicine and Pharmacy, University Mohamed Premier, Oujda, Morocco; 2Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy, University ...
Haddiya I, Valoti S
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Evaluation of the Triglyceride-Glucose Index with Different Generations of Beta-Adrenergic Blockers [PDF]
Background: Beta-blockers (β-blockers) work by blocking β-adrenergic receptors and differ in their metabolic effects and side effects. We aimed to compare the metabolic effects of different generations of β-blockers by evaluating the triglyceride-glucose
Atakan Arpaç +3 more
core +1 more source