Results 31 to 40 of about 757,965 (205)

Beta-Endorphin and Serotonin Levels in Individuals with Methamphetamine use Disorder

مجلة كلية الطب
Background: Alterations in the levels of beta-endorphins and serotonin are heavily involved in the mood dysregulation regularly observed in individuals with methamphetamine use disorder, with lower levels of these neurotransmitters contributing to mood ...
Noor H. Talib, Maysaa J. Majeed , Maher M. Hussein   +2 more
doaj   +1 more source

JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats

Molecular Pain, 2012
Background Proopiomelanocortin (POMC)-derived beta-endorphin1-31 from immune cells can inhibit inflammatory pain. Here we investigated cytokine signaling pathways regulating POMC gene expression and beta-endorphin production in lymphocytes to augment ...
Busch-Dienstfertig Melanie, Labuz Dominika, Wolfram Theresa, Vogel Nicole N, Stein Christoph   +4 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Analgesic effect of morphine: a role for beta-endorphin

, 1987
Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic beta-endorphin, a specific antiserum and human beta-endorphin fragment 6 31, a peptidergic beta-endorphin antagonist have been used in the attempt of selectively affecting the function
A. Brini, A.E. Panerai, P. Mantegazza, P. Sacerdote   +3 more
core   +1 more source

Effect of anaerobic bout using wingate cycle ergometer on pressure pain threshold in normal individuals

Indian Journal of Pain, 2017
Introduction: Published studies reveal that incremental graded and short term anaerobic exercise lead to an increase in beta-endorphin levels, the extent correlating with the lactate concentration.
Ajit Dabholkar, Aditya Andhansare, Tejashree Ajit Dabholkar   +2 more
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

[3H]-beta-endorphin binding in rat brain

, 1984
The binding of [3H]-beta-endorphin to rat brain homogenates is complex. Although Scatchard analysis of saturation studies yields a straight line, detailed competition studies are multiphasic, suggesting that even at low concentrations of the compound ...
N Johnson, GW Pasternak, RA Houghten
core   +1 more source

Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints

npj Parkinson's Disease
Pain control after deep brain stimulation (DBS) in Parkinson’s disease (PD) remains unclear. Following six months, subthalamic (STN)-DBS reduced sensory complaints related to parkinsonism and bodily discomfort, increasing central beta-endorphin level ...
Maria Gabriela S. Ghilardi, Ana Carolina P. Campos, Rubens G. Cury, Raquel C. R. Martinez, Rosana L. Pagano, Erich T. Fonoff   +5 more
doaj   +1 more source

Oral Self-Administration Of EtOH In Transgenic Mice Lacking Beta-Endorphin [PDF]

Impulse: The Premier Undergraduate Neuroscience Journal, 2007
EtOH modifies the production and/or release of endogenous opioid peptides, including -endorphin (Gianoulakis, 2004; Przewlocka et al., 1994; Schulz et al., 1980).
Stephani Allen, Kevin Karwan, Ashley Holloway, Sydney B. Williams, Judith E. Grisel   +4 more
doaj  

Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse. [PDF]

PLoS ONE, 2009
Secretion of gonadotropin-releasing hormone (GnRH) produced in neurons in the basal forebrain is the primary regulator of reproductive maturation and function in mammals.
Daniel R Ward, Fiona M Dear, Ian A Ward, Susan I Anderson, Daniel J Spergel, Paul A Smith, Francis J P Ebling   +6 more
doaj   +1 more source