β-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling [PDF]
Scientific Reports, 2023 Solar ultraviolet B (UVB) radiation triggers excessive inflammation, disrupting the epidermal barrier, and can eventually cause skin cancer. A previous study reported that under UVB irradiation, epidermal keratinocytes synthesize the proopiomelanocortin ...
Hyung-Su Kim +4 more
doaj +2 more sources
IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception [PDF]
Brain Sciences, 2023 Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 trigger the ...
Thiago Caetano Andrade Belo +7 more
doaj +2 more sources
β-Endorphin (an endogenous opioid) inhibits inflammation, oxidative stress and apoptosis via Nrf-2 in asthmatic murine model [PDF]
Scientific Reports, 2023 Asthma, a chronic respiratory disease is characterized by airway inflammation, remodelling, airflow limitation and hyperresponsiveness. At present, it is considered as an umbrella diagnosis consisting several variable clinical presentations (phenotypes ...
Vinita Pandey +4 more
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Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes [PDF]
Frontiers in Pharmacology, 2021 Cynandione A, an acetophenone isolated from Cynanchum Wilfordii Radix, exhibits antineuropathic pain effect. This study further explored the target molecule and signaling mechanisms underlying cynandione-A-induced antineuropathic pain.
Qiao-Qiao Han +5 more
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COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity [PDF]
Molecular Pain, 2020 This cross-sectional study investigated whether the catechol-O-methyltransferase (COMT) gene acts as a significant regulator of pain signaling pathways, regulates β-endorphin, and contributes to ethnic differences in pain sensitivity.
Feng Xu +12 more
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques [PDF]
International Journal of Endocrinology, 2020 β-Endorphin, an endogenous opioid peptide, and its μ-opioid receptor are expressed in brain, liver, and peripheral tissues. β-Endorphin induces endothelial dysfunction and is related to insulin resistance.
Taisuke Okano +10 more
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Molecular interpretation of ACTH-β-endorphin coaggregation: relevance to secretory granule biogenesis. [PDF]
PLoS ONE, 2012 Peptide/protein hormones could be stored as non-toxic amyloid-like structures in pituitary secretory granules. ACTH and β-endorphin are two of the important peptide hormones that get co-stored in the pituitary secretory granules. Here, we study molecular
Srivastav Ranganathan +5 more
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Peripartum Beta Endorphin levels in Relation to Labor Disorders and Post-Calving Reproductive Performance of Buffaloes. [PDF]
Journal of Animal and Poultry Production, 2016 The aim of this study was determine the relationship between plasma β-endorphin profiles in the peripheral blood circulation and cortisol concentrations during peri-partum (pre- and post-partum periods) of buffalo cows severed from dystocia, retained ...
H. Abou El-Ghait, O. El-Malky
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Endogenous opioid signaling in the retina modulates sleep/wake activity in mice
Neurobiology of Sleep and Circadian Rhythms, 2022 Circadian sleep/wake rhythms are synchronized to environmental light/dark cycles in a process known as photoentrainment. We have previously shown that activation of β-endorphin-preferring μ-opioid receptors (MORs) inhibits the light-evoked firing of ...
Casey-Tyler Berezin +5 more
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Physiological Reports, 2022 Exercise‐induced hypoalgesia (EIH) is characterized as the pain reduction after an exercise session and it seems to be related to the release of plasma β‐endorphin.
Marta Silva Santos +7 more
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