Results 31 to 40 of about 9,935 (130)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Naltrexone Protects Against Hypotension, Hyperthermia, and β-Endorphin Overproduction During Heatstroke in the Rat

Journal of Pharmacological Sciences, 2005
Heat stroke is characterized by hyperthermia, arterial hypotension, decreased baroreflex sensitivity, and increased serum levels of β-endorphin. Whereas naltrexone may have therapeutic potential in heat stroke, the underlying mechanism remains unclear ...
Yi-Ping Huang, Mao-Tsun Lin, Jwo-Sheng Chen, Pang-Yen Wu   +3 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Peripheral non-viral MIDGE vector-driven delivery of β-endorphin in inflammatory pain

Molecular Pain, 2009
Background Leukocytes infiltrating inflamed tissue produce and release opioid peptides such as β-endorphin, which activate opioid receptors on peripheral terminals of sensory nerves resulting in analgesia.
Busch Melanie, Labuz Dominika, Brack Alexander, Rittner Heike L, Mousa Shaaban A, Sitte Nicolle, Binder Waltraud, Schroff Matthias, Oswald Detlef, Machelska Halina, Wittig Burghardt, Schäfer Michael, Stein Christoph   +12 more
doaj   +1 more source

Step into action: how reminders shape engagement in fitness apps

Economica, EarlyView.
Abstract Regular exercise offers well‐documented health benefits, and mobile applications are increasingly used to promote physical activity. In this study, we conduct a large‐scale randomized controlled trial with 20,187 users of the WeWard app in France to evaluate the effectiveness of different message framings and intervention durations on app ...
Beatrice Braut, Claire Mollier, Sarah Zaccagni   +2 more
wiley   +1 more source

Heme-Induced Macrophage Phenotype Switching and Impaired Endogenous Opioid Homeostasis Correlate with Chronic Widespread Pain in HIV

Cells, 2023
Chronic widespread pain (CWP) is associated with a high rate of disability and decreased quality of life in people with HIV-1 (PWH). We previously showed that PWH with CWP have increased hemolysis and elevated plasma levels of cell-free heme, which ...
Tanima Chatterjee, Itika Arora, Lilly B. Underwood, Terry L. Lewis, Juan Xavier Masjoan Juncos, Sonya L. Heath, Burel R. Goodin, Saurabh Aggarwal   +7 more
doaj   +1 more source

ACTH suppression and adverse effects of cabergoline in horses with pituitary pars intermedia dysfunction

Equine Veterinary Education, EarlyView.
Summary Background The diagnosis and management of pituitary pars intermedia dysfunction (PPID) in horses includes evaluating abnormal plasma concentrations of adrenocorticotrophic hormone (ACTH). Treatment commonly includes the oral dopamine agonist pergolide mesylate, which suppresses the pathologic overproduction of ACTH.
A. Bracken, H. Tyra, M. Vetter, K. Kiger, S. Rao, L. Bass   +5 more
wiley   +1 more source

Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by Electroacupuncture

Molecular Pain, 2011
Background Electroacupuncture (EA) can produce analgesia by increasing the β-endorphin level and activation of peripheral μ-opioid receptors in inflamed tissues.
Su Tang-feng, Zhang Ling-hong, Peng Miao, Wu Cai-hua, Pan Wen, Tian Bo, Shi Jing, Pan Hui-lin, Li Man   +8 more
doaj   +1 more source

Screening of Asian Natural Materials to Promote β-Endorphin Synthesis

Natural Product Communications, 2023
Since the recent coronavirus disease 2019 pandemic and the lifestyle changes it necessitated, the demand for mental health treatment has skyrocketed, with long wait lists for both psychological and psychiatric care.
Masako Matsumoto, Maki Nagata, Yutaka Kuroki, Kuniyoshi Shimizu   +3 more
doaj   +1 more source

Effect of auricular point therapy on the psychological state and plasma β-endorphin level of patients with burning mouth syndrome

口腔疾病防治, 2023
Objective To observe the clinical effects of auricular point therapy on burning mouth syndrome (BMS) and its effect on the psychological state of patients and plasma β-endorphin.
LOU Jianing, ZHOU Haiwen , GE Shuyun
doaj   +1 more source