Results 61 to 70 of about 2,723 (173)

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

The Impact of Physical Activity on Depression Treatment: A Literature Review

Quality in Sport
Introduction Engaging in physical exercise can have a significant impact on the treatment of mild-to-moderate mental health conditions, including depression.
Daria Sieniawska, Julia Sieniawska, Patrycja Proszowska   +2 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

157 | A preliminary study on the interplay between serum neurotransmitter levels and the behavioral phenotype of canis familiaris

Journal of Biological Research
Domestication and selective breeding have profoundly shaped the behavioral phenotypes of domestic dogs, resulting in marked differences among breeds in temperament, motivation and stress reactivity.
Società Italiana di Biologia Sperimentale
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Spinal cord stimulation combined with exercise in patients diagnosed with persistent spinal pain syndrome. Study protocol for a randomized control trial.

PLoS ONE
IntroductionAdministration of spinal cord stimulation to individuals with PSPS-T1/2 may induce supraspinal descending activation. Similarly, exercise is recognized as a fundamental aspect of spinal pain management. Studies have demonstrated its impact on
J Vicente-Mampel, F Falaguera-Vera, D Sánchez-Poveda, F Hernández-Zaballos, M Martinez-Soler, P Blanco-Giménez, F J Sanchez-Montero   +6 more
doaj   +1 more source

The Evolutionary Biology of Female‐Biased Pain and Its Disorders

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT This article describes and evaluates a general evolutionary theory for explaining variation among individuals in sensitivity to pain, the Vulnerability‐Value‐Opportunity model. The model posits that pain sensitivity is mediated by vulnerability to fitness‐reducing injury (probabilities of damage, including from infection), Fisherian ...
Bernard Crespi
wiley   +1 more source

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Olivier Lavoie, Audrey Turmel, Axelle Khouma, Moein Minbashi Moeini, Chen Liu, Natalie J. Michael, Alexandre Caron   +6 more
wiley   +1 more source

Anterior Cervical Discectomy and Fusion Modulates Inflammatory Factors and Pain Mediators in Cervical Disc Herniation With Neurogenic Pain

Orthopaedic Surgery, Volume 18, Issue 4, Page 745-754, April 2026.
This study demonstrates that ACDF significantly reduces inflammatory factors and pain mediators, improves clinical symptoms and neuroelectrophysiological outcomes in cervical disc herniation with neurogenic pain, with comparable safety to conservative treatment.
Bing Wu, Xin He, Hongzhen Jiang, Xiujie Yan, Jun An, Xiaojin Guo, Xiaodong Pang, Baogan Peng   +7 more
wiley   +1 more source

Psychophysiological Biomarkers for the Effects of Yoga as an Alternative Therapy among Healthcare Professionals with Chronic Low Back Pain: A Randomized Controlled Trial

Journal of Nature and Science of Medicine
Aims: This trial investigates the effects of Sphinx Pose Yoga therapy on psychophysiological outcomes in healthcare professionals (HCPs) suffering from chronic low back pain (CLBP). By examining the changes in key biomarkers (Substance P, beta-endorphins,
Yusra Saleem, Shamoon Noushad, Sadaf Ahmed, Basit Ansari   +3 more
doaj   +1 more source

Pain perception in schizophrenia: influence of neuropeptides, cognitive disorders, and negative symptoms

Neuropsychiatric Disease and Treatment, 2015
Małgorzata Urban-Kowalczyk,1 Justyna Pigońska,2 Janusz Śmigielski3 1Department of Affective and Psychotic Disorders, Medical University of Łódź, Łódź, Poland; 2Department of Neurology and Movement Disorders, Medical University of Łó ...
Urban-Kowalczyk M, Pigońska J, Śmigielski J   +2 more
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