Results 11 to 20 of about 14,005 (251)

Genetic diversity of b-glucuronidase activity among 14 strains of the dominant human gut anaerobe Ruminococcus gnavus

Genetics and Molecular Biology, 2006
Bacterial beta-glucuronidase activity in the gut increases the enterohepatic circulation of toxic compounds and plays a major role in the etiology of colon cancer.
Diane Beaud, Monique Ladiré, Vasco Azevedo, Chantal Bridonneau, Jamila Anba-Mondoloni   +4 more
doaj   +1 more source

Synthesis, Molecular Docking and β-Glucuronidase Inhibitory Potential of Indole Base Oxadiazole Derivatives

Molecules, 2019
β-glucuronidase is a lysosomal glycosidase enzyme which catalyzes the extracellular matrix of cancer and normal cells and the glycosaminoglycans of the cell membrane, which is important for cancer cell proliferation, invasion, and metastasis.
El Hassane Anouar, Moustapha Eid Moustapha, Muhammad Taha, Mohammed H. Geesi, Zeinab R. Farag, Fazal Rahim, Noor Barak Almandil, Rai Khalid Farooq, Muhammad Nawaz, Ashik Mosaddik   +9 more
doaj   +1 more source

Nonhemocyte sources of selected lysosomal enzymes in Biomphalaria glabrata, B. tenagophila and B. straminea (Mollusca: Pulmonata)

Memorias do Instituto Oswaldo Cruz, 1981
The specific activities of acid phosphatase, alkaline phosphatase, β-glucuronidase, lysozymes, glutamate-oxalacetate transaminase and glutamate-pyruvate transaminate were determined in the head-foot and digestive gland of Brazilian Biomphalaria ...
Gary E. Rodrick, W. Monteiro, W. A. Sodeman Júnior   +2 more
doaj   +1 more source

Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity

BMC Microbiology, 2023
Background Irinotecan is a chemotherapeutic agent used to treat a variety of tumors, including colorectal cancer (CRC). In the intestine, it is transformed into SN-38 by gut microbial enzymes, which is responsible for its toxicity during excretion ...
Marwa S. Mahdy, Ahmed F. Azmy, Tarek Dishisha, Wafaa R. Mohamed, Kawkab A. Ahmed, Ahmed Hassan, Sahar El Aidy, Ahmed O. El-Gendy   +7 more
doaj   +1 more source

Polysaccharide monooxygenase-catalyzed oxidation of cellulose to glucuronic acid-containing cello-oligosaccharides

Biotechnology for Biofuels, 2019
Background Polysaccharide monooxygenases (PMOs) play an important role in the enzymatic degradation of cellulose. They have been demonstrated to able to C6-oxidize cellulose to produce C6-hexodialdoses. However, the biological function of C6 oxidation of
Jinyin Chen, Xiuna Guo, Min Zhu, Chen Chen, Duochuan Li   +4 more
doaj   +1 more source

Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers

Sultan Qaboos University Medical Journal, 2018
Objectives: This study aimed to establish lactate dehydrogenase (LDH) and β-glucuronidase as salivary biomarkers of periodontitis among smokers and non-smokers.
Syed A. Ali, Ravi L. Telgi, Amit Tirth, Irfan Q. Tantry, Abdul Aleem   +4 more
doaj   +1 more source

Food-Induced Hyperkinesis

Pediatric Neurology Briefs, 1992
The results of a controlled trial of hyposensitization with intradermal EPD (beta-glucuronidase and food antigens) in 40 children with the hyperkinetic syndrome are reported from the Universitatskinderklinik, Lindwurmstrasse, Munchen, Germany and The ...
J Gordon Millichap
doaj   +1 more source

Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements

Gut Microbes, 2022
The intestinal microbiota produces β-glucuronidase that plays an essential role in the metabolism of the immunosuppressant mycophenolate mofetil (MMF). This drug is commonly used in organ and hematopoietic cell transplantation (HCT), with variations in ...
Mohammad Haneef Khan, Guillaume C. Onyeaghala, Armin Rashidi, Shernan G. Holtan, Alexander Khoruts, Ajay Israni, Pamala A. Jacobson, Christopher Staley   +7 more
doaj   +1 more source

Chemical synthesis of all-trans retinoyl beta-glucuronide.

Journal of Lipid Research, 1985
All-trans retinoyl fluoride reacts with the 3,6-lactone of glucuronic acid in slightly alkaline solution to give the lactone of retinoyl beta-glucuronide, along with other retinoyl glucurono-lactones, in about 60% yield.
A B Barua, J A Olson
doaj   +1 more source

Quantification of an Antibody-Conjugated Drug in Fat Plasma by an Affinity Capture LC-MS/MS Method for a Novel Prenyl Transferase-Mediated Site-Specific Antibody–Drug Conjugate

Molecules, 2020
The novel prenyl transferase-mediated, site-specific, antibody−drug conjugate LCB14-0110 is comprised of a proprietary beta-glucuronide linker and a payload (Monomethyl auristatin F, MMAF, an inhibitor for tubulin polymerization) attached to human ...
Byeong ill Lee, Min-Ho Park, Jin-Ju Byeon, Seok-Ho Shin, Jangmi Choi, Yuri Park, Yun-Hee Park, Jeiwook Chae, Young G. Shin   +8 more
doaj   +1 more source