Results 41 to 50 of about 14,005 (251)
Metabolism of lithocholic acid in the rat: formation of lithocholic acid 3-O-glucuronide in vivo.
Journal of Lipid Research, 1990 Milligram amounts of [3 beta-3H]lithocholic (3 alpha-hydroxy-5 beta-cholanoic) acid were administered by intravenous infusion to rats prepared with a biliary fistula.
JM Little +4 more
doaj +1 more source
Phase II Metabolism of Asarone Isomers In Vitro and in Humans Using HPLC-MS/MS and HPLC-qToF/MS
Foods, 2021 (1) Background: Metabolism data of asarone isomers, in particular phase II, in vitro and in humans is limited so far. For the first time, phase II metabolites of asarone isomers were characterized and human kinetic as well as excretion data after oral ...
Lena Hermes +3 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Acephate is an organophosphate insecticide widely used. This pesticide can be metabolized into methamidophos, a molecule highly toxic. Both have demonstrated the ability to promote serious toxic effects on nontarget organisms and have been identified in surface waters around the world. Therefore, it is important to understand their behavior in
Mariana Laiz Silva de Lima +3 more
wiley +1 more source
Indonesian Journal of Biotechnology, 2015 This study was carried out to establish a stable genetic transformation in callus culture of Andrographispaniculata mediated by Agrobacterium tumefaciens. The leaf disks of A. paniculata were infected with A.
Erly Marwani +2 more
doaj
Journal of Lipid Research, 1984 We have isolated an unusual acidic glycolipid which was detected in the lower phase of the Folch partition of the total lipid extract of human liver during a routine isolation of glycosphingolipids.
I A Muhiudeen +6 more
doaj +1 more source
In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini +5 more
wiley +1 more source
Small, EarlyView.This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack +9 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2022 Jowita Biernawska,1 Katarzyna Kotfis,2 Jolanta Szymańska-Pasternak,3 Anna Bogacka,4 Joanna Bober3 1Department of Anesthesiology and Intensive Therapy, Pomeranian Medical University, Szczecin, Poland; 2Department of Anesthesiology, Intensive ...
Biernawska J +4 more
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Brain Pathology, EarlyView.14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García +13 more
wiley +1 more source
A rare late progression form of Sly syndrome mucopolysaccharidosis
JIMD Reports, 2019 Mucopolysaccharidoses VII, or Sly syndrome, is linked to mutations in the beta‐glucuronidase encoding gene. Sly syndrome is a rare condition and presentation is highly variable, ranging from a prenatal form with severe, lethal fetal hydrops to more ...
Nathalie Guffon +2 more
doaj +1 more source