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Hypersensitivity Reactions to Beta-lactams
2013Beta-lactam antibiotics (BLs) are the most frequent cause of hypersensitivity reactions mediated by specific immunological mechanisms, with two main types, IgE reactions or T-cell-dependent responses. From a practical point of view, these reactions can be classified into immediate, for those appearing within 1 h after drug intake, and non-immediate ...
Maria J, Torres +3 more
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Continuous infusion of beta-lactams
Current Opinion in Critical Care, 2007Continuous infusion of beta-lactam antibiotics is becoming increasingly popular. The background and current clinical evidence are discussed. Tools to apply continuous infusion are analyzed.One randomized controlled trial in an ICU setting and two nonrandomized controlled trials have shown continuous infusion to be more beneficial than intermittent ...
Johan W, Mouton, Alexander A, Vinks
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Advances in Beta-Lactam Antibiotics
2013The β-lactam antibiotics continue providing health to the world population by virtue of industrial production and discoveries of new molecules with useful activities. Sales of these remarkable compounds, including penicillins, cephalosporins, cefoxitin, monobactams, clavulanic acid, and carbapenems, have reached over $20 billion dollars per year ...
Barredo J.-L., Ozcengiz G., Demain A.L.
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