Results 21 to 30 of about 48,747 (238)

Identification of Delta-beta Thalassemia in a Family with Elevated Hb F: A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2020
Delta-beta Thalassemia is a rare variant of thalassemia with elevated Hb F. Heterozygous and homozygous state of delta-beta thalassemia present with features similar to Hereditary Persistence of Fetal Haemoglobin (HPFH) and beta thalassemia ...
Varun Kumar Singh, Pavithra Prabhakar, Sushma Belurkar, Chethan Manohar   +3 more
doaj  

Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]

, 2017
Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R., Chondrou, Vasiliki, John, Anne, Kastrinou, Vlasia, Katsila, Theodora, Kolovos, Petros, Kourakli, Alexandra, Papachatzopoulou, Adamantia, Patrinos, George P., Pavlidaki, Alexia, Sgourou, Argyro, Symeonidis, Argiris   +11 more
core   +5 more sources

BETA THALASSEMIA TRAIT;

The Professional Medical Journal, 2018
Objectives: To assess the sensitivity of the various discrimination indicesas screening test in beta-thalassemia trait patients in our population. Study design: Crosssectional descriptive study. Period: 1-Sep 2012 to 31-Jan 2013 (5 months). Settings: PathologyDepartment, District Head Quarters (DHQ) Hospital, Rawalpindi.
Muhammad Ihtesham Khan, Hamid Nawaz Khan, Muhammad Usman   +2 more
openaire   +4 more sources

The effects of group play therapy on self-concept among 7 to 11 year-old children suffering from thalassemia major [PDF]

, 2016
Background: Children suffering from thalassemia have higher levels of depression and lower levels of self-concept. Objectives: The aim of this study was to determine if group play therapy could significantly increase self-concept among children with ...
Dastoorpoor, M., Estebsari, F., Ghasemi, A., Nejad, L.B., Taghavi, T., Tomaj, O.K.   +5 more
core   +1 more source

Takayasu's arteritis presenting with temporary loss of vision in a 23-year-old woman with beta thalassemia trait: a case report [PDF]

, 2011
Introduction The simultaneous presence of Takayasu's arteritis and beta thalassemia trait is a rare combination. To the best of our knowledge, this is the first case report on Takayasu's arteritis and beta thalassemia presenting together.
Shabbir Fahad A, Ishaq Mohammad G
core   +1 more source

The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells. [PDF]

, 2015
Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene.
Baldwin, Kismet M, Campo-Fernandez, Beatriz, Cooper, Aaron R, Hoban, Megan D, Hollis, Roger P, Kaufman, Michael L, Kohn, Donald B, Lumaquin, Dianne, Romero, Zulema, Senadheera, Shantha, Urbinati, Fabrizia, Wang, Xiaoyan, Wherley, Jennifer   +12 more
core   +4 more sources

Prevalence of the C282Y and H63D mutations of the HFE hemochromatosis gene in Azerian major β-thalassemia and iron overload [PDF]

, 2016
In this study, we have determined the allele frequency of HFE mutations H63D and C282Y in a group of Azerian beta-thalassemia major patients. These two mutations are implicated in hereditary hemochromatosis among Caucasians.
Ahmadi, M. R. H., Akbari, A. A. M., Feyzi, A. A. H. P., Ghaderi, A., Hagh, M. F., Hiradfar, A., Hosseini, E.   +6 more
core   +1 more source

Effects of vitamin e and zinc supplementation on antioxidants in beta thalassemia major patients [PDF]

, 2011
Objective: In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant ...
Aboomardani, M., Arefhosseini, S.-R., Joshaghani, H., Keshtkar, A., Rafraf, M., Rashidi, M.   +5 more
core   +1 more source

.BETA.+-Thalassemia with Hemochromatosis.

Internal Medicine, 1992
A 64-year-old man was admitted due to ascites. Laboratory data showed hemoglobin 6.7 g/dl, mean corpuscular volume 82 fl, and ferritin 2,360 ng/ml. Liver biopsy showed hemochromatosis. The diagnosis of beta-thalassemia was suggested by a decreased ratio of beta/alpha-globin synthesis in vitro (0.26).
Masakatsu UCHIHARA, Toshihiko NOUCHI, Teruo HARANO, Michio YAMANE, Hideki SAKAI, Kazuhiko TAKABE, Sunao MAE, Shinya MAEKAWA, Toshiko FUKUMA, Yasuhiro MIYAHARA, Chifumi SATO, Fumiaki MARUMO   +11 more
openaire   +3 more sources

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source