Results 21 to 30 of about 607,752 (259)

CRISPR Gene Therapy: A Promising One-Time Therapeutic Approach for Transfusion-Dependent β-Thalassemia—CRISPR-Cas9 Gene Editing for β-Thalassemia

, 2023
β-Thalassemia is an inherited hematological disorder that results from genetic changes in the β-globin gene, leading to the reduced or absent synthesis of β-globin.
Gayathri N. Silva, Kesari Warnakulasuriya, Udani Gamage, Sonali Hansika   +3 more
core   +1 more source

.BETA.+-Thalassemia with Hemochromatosis.

Internal Medicine, 1992
A 64-year-old man was admitted due to ascites. Laboratory data showed hemoglobin 6.7 g/dl, mean corpuscular volume 82 fl, and ferritin 2,360 ng/ml. Liver biopsy showed hemochromatosis. The diagnosis of beta-thalassemia was suggested by a decreased ratio of beta/alpha-globin synthesis in vitro (0.26).
UCHIHARA, Masakatsu, NOUCHI, Toshihiko, HARANO, Teruo, YAMANE, Michio, SAKAI, Hideki, TAKABE, Kazuhiko, MAE, Sunao, MAEKAWA, Shinya, FUKUMA, Toshiko, MIYAHARA, Yasuhiro, SATO, Chifumi, MARUMO, Fumiaki   +11 more
openaire   +3 more sources

The impact of iron deficiency on the diagnostic level of HbA2 in beta- thalassemia trait from the Sulaimani hemoglobinopathies screening program.

Advanced Medical Journal, 2022
Background and objectives: The identification of carriers of beta- thalassemia depends on the detection of a high level of hemoglobin A2. The hemoglobin A2 level is influenced by some elements including iron.
Awaz Ahmed Kamal Shalli, Sana Dlawar Jalal, Dler Jaza Mohammed   +2 more
doaj   +1 more source

Study of blood groups and Rhesus factor in beta thalassemia patients undergoing blood transfusions

, 2021
Beta thalassemia is the most common genetic blood disease, affecting millions of people in both developing and developed countries including Iraq. Patients with thalassemia require frequent blood transfusions, which can cause a variety of complications ...
Maha Tareq Hussein
core   +1 more source

Beta-Thalassemia major and pregnancy

Bratislava Medical Journal, 2013
It was studied the clinical management and the medical outcomes of 6 pregnancies in 5 women affected by Beta Thalassemia major, based on last guidelines and pharmacological treatments.Paediatric Department and Department of Obstetrics and Gynaecology of the University of Catania.These patients were taken among a group of 116 women affected by beta ...
Gulino F. A., Vitale S. G., Fauzia M., Cianci S., Pafumi C., Palumbo M. A.   +5 more
openaire   +8 more sources

Highlights on the Luspatercept Treatment in Thalassemia

, 2023
Luspatercept has been shown to act as a ligand trap, selectively suppressing the deleterious effects of GDF11 that blocks terminal erythroid maturation, restoring normal erythroid differentiation and improving anemia in animal models of &beta ...
Yesim Aydinok
core   +1 more source

Beta-thalassemia and pulmonary function.

Haematologica, 1999
The survival of patients with beta-thalassemia major and intermedia has improved considerably. This has focused attention on the long-term sequelae of the disease itself and its treatment. The effect of hemosiderosis in major organs (heart, liver, etc) are well-recognized, but the pathophysiology of any lung damage is less clearly understood.
G. Piatti, L. Allegra, U. Ambrosetti, M.D. Cappellini, F. Turati, G. Fiorelli   +5 more
openaire   +3 more sources

Newborn Screening Practices for Beta-Thalassemia in the United States

International Journal of Neonatal Screening, 2021
Beta-thalassemia, a heritable condition of abnormal hemoglobin production, is not a core condition on the United States Recommended Uniform Screening Panel (RUSP) for state and territorial newborn screening (NBS) programs.
Michael A. Bender, Mary Hulihan, Mary Christine Dorley, Maria del Pilar Aguinaga, Jelili Ojodu, Careema Yusuf   +5 more
doaj   +1 more source

Identification of Delta-beta Thalassemia in a Family with Elevated Hb F: A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2020
Delta-beta Thalassemia is a rare variant of thalassemia with elevated Hb F. Heterozygous and homozygous state of delta-beta thalassemia present with features similar to Hereditary Persistence of Fetal Haemoglobin (HPFH) and beta thalassemia ...
Varun Kumar Singh, Pavithra Prabhakar, Sushma Belurkar, Chethan Manohar   +3 more
doaj  

Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment. [PDF]

, 2008
Background: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible ...
Tan, RS, Tan Ru, Chan, G.C.F, He, T, Fogel Mark A, Firmin David N, Au, W-Y, Pennell, Dudley J., Chan, GCF, Fogel, MA, Lam, W.M, Aydinok, Y, Chu, WCW, He, Taigang, Cohen, AR, Ng, I, Chu Winnie CW, Cohen, Alan R., Pennell, DJ, Pennell Dudley J, Firmin, D.N, Chu, W.C.W, Biceroglu, S, Fogel, M.A, Tan, R.S, Lam, WM, Chan Godfrey CF, Lam Wynnie M, Firmin, David N., Biceroglu Selen, Aydinok Yesim, Aydinok, Yesim, Firmin, DN, Kirk, Paul, Fogel, Mark A., Pennell, D.J, Ng Ivy, Kirk, P, Au, Wing-Yan, Tan, Ru San, Au, WY, He Taigang, Kirk Paul, Chan, GC, Biceroglu, Selen, Cohen, A.R, Au Wing-Yan, Chu, Winnie C. W., Chu, WC, Au, W.-Y, Lam, Wynnie M., Cohen Alan R, Ng, Ivy, Chan, Godfrey C. F.   +53 more
core   +1 more source