Transcriptional regulators of fetal hemoglobin [PDF]
Hematology, Transfusion and Cell TherapySickle cell anemia is a hereditary disease caused by sickle-shaped red blood cells that can lead to vaso-occlusive crises. Treatment options are currently limited, highlighting the need to develop new clinical approaches.
Gabriela Pereira dos Santos +5 more
doaj +4 more sources
Hereditary persistence of fetal hemoglobin
Asian Journal of Transfusion Science, 2020 Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.
Dharmesh Chandra Sharma +5 more
doaj +3 more sources
Unexpected absence of fetal hemoglobin induction by lenalidomide in a patient with sickle cell anemia with concurrent multiple myeloma [PDF]
Orphanet Journal of Rare DiseasesSickle cell anemia (SCA) and multiple myeloma (MM) are debilitating hematologic diseases impacting hemoglobin and plasma cells, respectively. Despite differing origins, they share overlapping clinical features including bone pain and anemia.
Rasmus Rønnemoes +7 more
doaj +2 more sources
A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds [PDF]
HemaSphereReactivation of fetal hemoglobin expression alleviates the symptoms associated with β‐globinopathies, severe hereditary diseases with significant global health implications due to their high morbidity and mortality rates.
Thijs C. J. Verheul +15 more
doaj +2 more sources
Agentes indutores da síntese de hemoglobina fetal Fetal hemoglobin inducing factors [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2007 Anemia falciforme é uma doença heterogênea caracterizada por uma grande variabilidade clínica. Desde as primeiras observações desta doença, foi visto que aumento no nível de hemoglobina fetal (HbF) estava associado com manifestações clínicas mais brandas,
Maria Stella Figueiredo
doaj +4 more sources
The Clinical Approach toward Hereditary Persistence of Fetal Hemoglobin: A Case Report
Iranian Journal of Allergy, Asthma and Immunology, 2022 Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin.
Afshin Ghaderi +3 more
doaj +1 more source
Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. [PDF]
PLoS ONE, 2013 Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease,
Nancy S Green +12 more
doaj +1 more source
Fetomaternal hemorrhage - case report
Journal of Education, Health and Sport, 2022 Maternal fetal leakage (FMH) is a well-known cause of fetal anemia. We define it as the transition of the fetal erythrocytes into the maternal circulation. Its severity is determined by measuring the level of fetal hemoglobin in the mother's blood using
Jakub Gruszka +3 more
doaj +1 more source
Perspective: A novel prognostic for sickle cell disease
Saudi Journal of Medicine and Medical Sciences, 2018 Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski +3 more
doaj +1 more source
MR imaging–derived oxygen-hemoglobin dissociation curves and fetal-placental oxygen-hemoglobin affinities [PDF]
, 2016 PURPOSE: To generate magnetic resonance (MR) imaging–derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level–dependent (BOLD) T2* and oxygen ...
Akselrod-Ballin, Ayelet +6 more
core +2 more sources