Results 31 to 40 of about 72,054 (299)
eLife, 2022 Naturally occurring point mutations in the HBG promoter switch hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary persistence of fetal hemoglobin (HPFH) and ameliorate the clinical severity.
Nithin Sam Ravi +24 more
doaj +1 more source
The effect of maternal hemoglobin concentration on fetal birth weight according to trimesters [PDF]
, 2015 Conclusions: Low hemoglobin concentrations in the first trimester of gestation seem to be associated with low fetal birth weights. Anemia can directly cause poor in utero fetal growth due to inadequate oxygen flow to the placental tissue or it can be an ...
Bulent Kostu +7 more
core +1 more source
Breaking Free from Your Fetal Chains: A Case-Based Review of the Literature on Gamma Chain Variant Hemoglobinopathies [PDF]
Neonatal Medicine, 2023 Methemoglobinemia is a dyshemoglobinemia characterized by cyanosis and reduced oxygen saturation with increased methemoglobin values. The etiology may be congenital or acquired, with the latter being more common.
Pearl Mary Varughese +3 more
doaj +1 more source
Keeping fetal hemoglobin in the loop [PDF]
Cell Cycle, 2014 Sickle cell disease (SCD) is caused by a point mutation in the adult type β-globin gene. The faulty β-globin chain triggers hemoglobin polymerization, promoting red blood cell sickling. Altered red blood cell shape causes occlusion of small blood vessels, leading to multi-organ damage and limiting life expectancy to 40–50 y of age.
Jeremy D, Grevet, Gerd A, Blobel
openaire +2 more sources
Polymorphism In The Hmox1 Gene Is Associated With High Levels Of Fetal Hemoglobin In Brazilian Patients With Sickle Cell Anemia. [PDF]
, 2015 The aim of this study was to investigate the association between three polymorphisms involved in the oxidative stress pathway and fetal hemoglobin (Hb F) levels in patients with sickle cell anemia in a Brazilian population. One hundred and seven patients
Oliveira, Mariana B +9 more
core +3 more sources
Revista Brasileira de Hematologia e Hemoterapia, 2012 BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers.
Darcielle Bruna Dias Elias +5 more
doaj +1 more source
Fetal cells in maternal circulation : fetal cell separation and FISH analysis [PDF]
, 2005 This work focuses on the isolation of fetal cells from the blood of pregnant women, with the aim of developing safe, efficacious, non-invasive alternatives for prenatal diagnosis.
Babochkina, Tatiana Ivanovna
core +1 more source
Sickle cell disease and fetal hemoglobin
Saudi Journal of Medicine and Medical Sciences, 2018 Alicia Rivera
doaj +3 more sources
Correlation of fetal hemoglobin in different cancer patients and sickle cell anaemia: A review [PDF]
, 2021 Fetal hemoglobin is the main hemoglobin during gestation period. But this globin chain is replaced and is taken over by adult hemoglobin. Sometimes this switch from fetal to adult fails to occur leading to production of fetal hemoglobin as in case of ...
Jan Peerzada Fawad ullah, Ayesha Shahid
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2019 Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clinically
Christopher T. Lux +13 more
doaj +1 more source