Results 31 to 40 of about 114,148 (300)
Association of HMIP1 C-893A polymorphism and disease severity in patients with sickle cell anemia
Hematology, Transfusion and Cell Therapy, 2021 Introduction: Sickle cell anemia (SCA) is a Mendelian disorder with a heterogeneous clinical course. The reasons for this phenotypic diversity are not entirely established, but it is known that high fetal hemoglobin levels lead to a milder course of the ...
Diego A. Pereira-Martins +9 more
doaj +1 more source
Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model
Haematologica, 2010 Hydroxyurea has proven clinical efficacy in patients with sickle cell disease. Potential mechanisms for the beneficial effects include fetal hemoglobin induction and the reduction of cell adhesive properties, inflammation and hypercoagulability.
Jeffrey D. Lebensburger +4 more
doaj +1 more source
Metabolic persistence of fetal hemoglobin [PDF]
Blood, 1995 Hereditary persistence of fetal hemoglobin (HPFH) has typically been ascribed to mutations in the beta-globin gene cluster. Pharmacologic agents, including the short-chain fatty acid butyrate, have been shown to upregulate fetal and embryonic globin gene expression. In this report we investigate the possibility that metabolic derangements characterized
J A, Little +3 more
openaire +2 more sources
What influences Hb fetal production in adulthood?
Revista Brasileira de Hematologia e Hemoterapia, 2011 Human hemoglobin genes are located in α and β globin gene clusters in chromosomes 16 and 11, respectively. Different types of hemoglobin are synthesized according to the stage of development with fetal hemoglobin (α2γ2) (Hb F) being ...
Gisele Cristine de Souza Carrocini +2 more
doaj +1 more source
Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: an interventional study [PDF]
, 2018 The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a ...
Antimo Cutone +6 more
core +2 more sources
Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia [PDF]
, 2017 Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
Hodges, James S. +8 more
core +2 more sources
BMC Pregnancy and Childbirth, 2018 Background Complete blood count is one of the routinely advised blood investigation during pregnancy. It is also utilized as a diagnostic tool for neonatal anemia, sepsis and determining hemostatic status of the newborn.
Sameer Timilsina +5 more
doaj +1 more source
Haematological Characterisation and Molecular Basis of Asian Indian Inversion Deletions Delta Beta Thalassemia: A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2014 The hereditary persistence of fetal hemoglobin (HPFH) and delta beta thalassemia are heterogeneous disorders characterised by increased levels of fetal hemoglobin and high level of this Hb continues in adulthood.
Jitender Mohan Khunger +4 more
doaj +1 more source
Hemoglobin FHouston: A Fetal Variant [PDF]
Blood, 1966 Abstract A fetal hemoglobin variant, designated hemoglobin FHouston, was found in the cord blood sample of a healthy, term Negro infant. The variant, comprising about 15 per cent of the total cord blood hemoglobin, diminished concomitantly with hemoglobin F, and it was barely detectable in the blood when the infant was 4 months old.
R G, Schneider, R T, Jones, K, Suzuki
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source