Results 41 to 50 of about 1,339,121 (337)
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression
bioRxiv, 2020 Metazoan transcription factors typically regulate large numbers of genes. Here we identify via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA binding protein that in human erythroid cells directly and measurably activates only one gene, the NuRD ...
Xian-Jiang Lan +19 more
semanticscholar +1 more source
Flowcytometric assessment of fetomaternal hemorrhage during external cephalic version at term [PDF]
, 2008 External cephalic version (ECV) at term is a safe procedure and reduces the incidence of cesarean sections for breech presentation. One of the known complications, however, is an ECV-related disruption of the placental barrier and a subsequent ...
Toth, Bettina +13 more
core +2 more sources
Hydroxyurea ameliorates mouse hypoxia through inducing embryonic hemoglobin
陆军军医大学学报, 2023 Objective To investigate the ameliorative effect and mechanism of hydroxyurea (HU) on hypoxia mice in a closed environment. Methods Sixty male C57BL/6J mice (6~8 weeks old, weighing 18~22 g) were randomly divided into normoxia control group (NC, n=10 ...
ZHOU Xiaoying +4 more
doaj +1 more source
Science Advances, 2020 Editing the fetal γ-globin promoters in hematopoietic stem cells from sickle cell disease patients induces therapeutic γ-globin levels. Sickle cell disease (SCD) is caused by a single amino acid change in the adult hemoglobin (Hb) β chain that causes Hb ...
Leslie Weber +18 more
semanticscholar +1 more source
The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]
, 1974 For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core +1 more source
Anemia, 2013 Objectives. To compare current criteria for severe fetal anemia diagnosis. Methodology. A cohort study analyzed 105 alloimmunized fetuses that underwent cordocentesis due to risk of anemia.
Zilma Silveira Nogueira Reis +5 more
doaj +1 more source
Scientific Reports, 2020 β-hemoglobinopathies are caused by abnormal or absent production of hemoglobin in the blood due to mutations in the β-globin gene (HBB). Imbalanced expression of adult hemoglobin (HbA) induces strong anemia in patients suffering from the disease. However,
Andrés Lamsfus-Calle +12 more
semanticscholar +1 more source
Keeping fetal hemoglobin in the loop [PDF]
Cell Cycle, 2014 Sickle cell disease (SCD) is caused by a point mutation in the adult type β-globin gene. The faulty β-globin chain triggers hemoglobin polymerization, promoting red blood cell sickling. Altered red blood cell shape causes occlusion of small blood vessels, leading to multi-organ damage and limiting life expectancy to 40–50 y of age.
Jeremy D, Grevet, Gerd A, Blobel
openaire +2 more sources
Blood, 2020 Reactivation of fetal hemoglobin remains a critical goal in the treatment of patients with sickle cell disease and β-thalassemia. Previously, we discovered that silencing of the fetal γ-globin gene requires the erythroid-specific eIF2α kinase HRI ...
Peng Huang +12 more
semanticscholar +1 more source
, 2022 Objectives: To establish whether a correlation exists between the fetal middle cerebral artery peak systolic velocity (MCA PSV) and fetal hemoglobin levels before intrauterine transfusion (IUT) in cases of severe fetal anemia. Methods: This was a single-
Hye-Sung Won +6 more
core +1 more source