Results 61 to 70 of about 114,148 (300)

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin

Haematologica, 2011
The persistence of high fetal hemoglobin level in adults may ameliorate the clinical phenotype of beta-thalassemia and sickle cell anemia. Several genetic variants responsible for hereditary persistence of fetal hemoglobin, linked and not linked to the ...
Stefania Satta, Lucia Perseu, Paolo Moi, Isadora Asunis, Annalisa Cabriolu, Liliana Maccioni, Franca Rosa Demartis, Laura Manunza, Antonio Cao, Renzo Galanello   +9 more
doaj   +1 more source

The mRNA-Binding Protein IGF2BP1 Restores Fetal Hemoglobin in Cultured Erythroid Cells from Patients with β-Hemoglobin Disorders

Molecular Therapy: Methods & Clinical Development, 2020
Sickle cell disease (SCD) and β-thalassemia are caused by structural abnormality or inadequate production of adult hemoglobin (HbA, α2β2), respectively.
Christopher B. Chambers, Jeffrey Gross, Katherine Pratt, Xiang Guo, Colleen Byrnes, Y. Terry Lee, Donald Lavelle, Ann Dean, Jeffery L. Miller, Andrew Wilber   +9 more
doaj   +1 more source

Vitamin A and zinc supplementation among pregnant women to prevent placental malaria: a randomized, double-blind, placebo-controlled trial in Tanzania [PDF]

, 2017
BACKGROUND: Malaria causes nearly 200 million clinical cases and approximately half a million deaths each year, primarily in sub-Saharan Africa.1 The risk of malaria increases during pregnancy,2 a period during which its prevention is especially ...
Abioye, Aijibola Ibraheem, Aboud, Said, Darling, Anne Marie, Duggan Christopher, Etheredge, Analee J., Fawzi, Wafaie W., Gunaratna, Nilupa S., Hamer, Davidson H., Kain, Kevin C., Mongi, Robert, Mugusi, Ferdinand M., Roberts, Drucilla, Spiegelman, Donna   +12 more
core   +1 more source

Bioinspired, Mitochondria‐Targeted Single‐Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​

Advanced Materials, EarlyView.
A bioinspired nanozyme—triphenylphosphonium (TPP)‐dendritic mesoporous silica nanoparticle (DMSN)‐Fe/Cu—mimics mitochondrial complex IV and targets mitochondria to regulate cellular energy metabolism. This approach markedly boosts bone regeneration in vivo, as demonstrated by enhanced bone volume and mineral density in critical‐sized bone defects rat ...
Yuwen Wang, Xinzhi Liang, Tiandi Xiong, Zheng Zhong, Ning Zhang, Boguang Yang, Dong Li, Qiongjiao Zeng, Xian Chen, Yiting Lei, Shangsi Chen, Chao Zheng, Liu Yang, Wei Huang, Rocky S. Tuan, Denghui Xie, Zhong Alan Li   +16 more
wiley   +1 more source

Fetal hemoglobin silencing in humans

Blood, 2006
AbstractInterruption of the normal fetal-to-adult transition of hemoglobin expression should largely ameliorate sickle cell and beta-thalassemia syndromes. Achievement of this clinical goal requires a robust understanding of gamma-globin gene and protein silencing during human development.
Patricia A, Oneal, Nicole M, Gantt, Joseph D, Schwartz, Natarajan V, Bhanu, Y Terry, Lee, John W, Moroney, Christopher H, Reed, Alan N, Schechter, Naomi L C, Luban, Jeffery L, Miller   +9 more
openaire   +3 more sources

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders

International Journal of Hematology-Oncology and Stem Cell Research, 2013
Objective: The use of fetal hemoglobin (HbF) inducer drugs is considered as a novel approach in treatment of β-hemoglobinopathies, especially β- thalassemia and sickle cell disease. HbF inducers including hydroxyurea, histone deacetylase (HDAC) inhibitor
Fatemeh Salari, Mohammad Shahjahani, Seyed Ahmad Hosseini, Ali Dehghani Fard, Kaveh Jaseb   +4 more
doaj   +2 more sources

Serum-free Erythroid Differentiation for Efficient Genetic Modification and High-Level Adult Hemoglobin Production

Molecular Therapy: Methods & Clinical Development, 2018
In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current erythroid differentiation methods are encumbered by modest transduction rates and high baseline fetal ...
Naoya Uchida, Selami Demirci, Juan J. Haro-Mora, Atsushi Fujita, Lydia N. Raines, Matthew M. Hsieh, John F. Tisdale   +6 more
doaj   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source