Results 61 to 70 of about 1,339,121 (337)

FIGO consensus guidelines on intrapartum fetal monitoring: Cardiotocography [PDF]

, 2015
Intermittent auscultation is the technique used to listen to the fetal heart rate (FHR) for short periods of time without a display of the resulting pattern.
Chandraharan, Edwin, Downe, Soo, Spong, Catherine Y, Spong, CY, Catherine Y. Spong, Chandraharan, E, FIGO, Intrapartum Fetal Monitoring Expert Consensus Panel, Ayres-de-Campos, Diogo, Lewis, D, FIGO Intrapartum, Fetal Monitoring Expert Consensus Panel, Ayres-de-Campos, D, Diogo Ayres‐de‐Campos, Edwin Chandraharan, Surbek, Daniel, Spong, Catherine Y., Lewis, Debrah   +15 more
core   +2 more sources

High Levels Of Human γ-globin Are Expressed In Adult Mice Carrying A Transgene Of The Brazilian Type Of Hereditary Persistence Of Fetal Hemoglobin (aγ -195)

, 2015
Hereditary persistence of fetal hemoglobin (HPFH) is characterized by increased levels of Hb F during adult life. Nondeletional forms of HPFH are characterized by single base mutations in the Aγ and Gγ promoters, resulting in an increase of Hb F ranging ...
Da Cunha A.F., Corra Passos L.A., Costa F.F., Gimenes A.P., Saad S.T.O., Brugnerotto A.F., Barbosa De Melo M., Finzi Corat M.A., Bodine D., Devlin E.E.   +9 more
core   +2 more sources

Association of HMIP1 C-893A polymorphism and disease severity in patients with sickle cell anemia

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Sickle cell anemia (SCA) is a Mendelian disorder with a heterogeneous clinical course. The reasons for this phenotypic diversity are not entirely established, but it is known that high fetal hemoglobin levels lead to a milder course of the ...
Diego A. Pereira-Martins, Igor F. Domingos, Edis Belini-Junior, Juan L. Coelho-Silva, Isabel Weinhäuser, Aderson S. Araújo, Clarisse L. Lobo, Claudia R. Bonini-Domingos, Marcos A. Bezerra, Antonio R. Lucena-Araujo   +9 more
doaj   +1 more source

Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model

Haematologica, 2010
Hydroxyurea has proven clinical efficacy in patients with sickle cell disease. Potential mechanisms for the beneficial effects include fetal hemoglobin induction and the reduction of cell adhesive properties, inflammation and hypercoagulability.
Jeffrey D. Lebensburger, Tamara I. Pestina, Russell E. Ware, Kelli L. Boyd, Derek A. Persons   +4 more
doaj   +1 more source

Metabolic persistence of fetal hemoglobin [PDF]

Blood, 1995
Hereditary persistence of fetal hemoglobin (HPFH) has typically been ascribed to mutations in the beta-globin gene cluster. Pharmacologic agents, including the short-chain fatty acid butyrate, have been shown to upregulate fetal and embryonic globin gene expression. In this report we investigate the possibility that metabolic derangements characterized
J A, Little, N J, Dempsey, M, Tuchman, G D, Ginder   +3 more
openaire   +2 more sources

What influences Hb fetal production in adulthood?

Revista Brasileira de Hematologia e Hemoterapia, 2011
Human hemoglobin genes are located in α and β globin gene clusters in chromosomes 16 and 11, respectively. Different types of hemoglobin are synthesized according to the stage of development with fetal hemoglobin (α2γ2) (Hb F) being ...
Gisele Cristine de Souza Carrocini, Paula Juliana Antoniazzo Zamaro, Claudia Regina Bonini-Domingos   +2 more
doaj   +1 more source

Evaluation of a portable hemoglobin photometer in pregnant women in a high altitude area: a pilot study. [PDF]

, 2009
BACKGROUND: Anemia is a widespread public health problem associated with an increased risk of morbidity and mortality, especially in pregnant women. This study examined the agreement between a portable hemoglobin photometer and a laboratory analyzer in ...
Xing Yuan, Bianba Zhuoma, Zhou, Xiaoyan, Yan Hong, Zhou Xiaoyan, Xiaoyan Zhou, Duolao Wang, Xing, Yuan, Zhuoma, Bianba, Dang, Shaonong, Yuan Xing, Wang, Duolao, Wang Duolao, Dang Shaonong, Zhuoma Bianba, Shaonong Dang, Yan, Hong, Hong Yan   +17 more
core   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Haematological Characterisation and Molecular Basis of Asian Indian Inversion Deletions Delta Beta Thalassemia: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2014
The hereditary persistence of fetal hemoglobin (HPFH) and delta beta thalassemia are heterogeneous disorders characterised by increased levels of fetal hemoglobin and high level of this Hb continues in adulthood.
Jitender Mohan Khunger, Monika Gupta, Rekha Singh, Rohit Kapoor, Hare Ram Pandey   +4 more
doaj   +1 more source

Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease.

European Journal of Pharmacology, 2019
Hemoglobinopathies, such as β-thalassemia, and sickle cell disease (SCD) are caused by abnormal structure or reduced production of β-chains and affect millions of people worldwide. Hereditary persistence of fetal hemoglobin (HPFH) is a condition which is
M. A. Khosravi, M. Abbasalipour, J. Concordet, J. Berg, S. Zeinali, A. Arashkia, K. Azadmanesh, T. Buch, M. Karimipoor   +8 more
semanticscholar   +1 more source