Results 51 to 60 of about 1,339,121 (337)

Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline

Revista Brasileira de Hematologia e Hemoterapia, 2012
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers.
Darcielle Bruna Dias Elias, Lilianne Brito da Silva Rocha, Maritza Barbosa Cavalcante, Alano Martins Pedrosa, Izabel Cristina Bandeira Justino, Romélia Pinheiro Gonçalves   +5 more
doaj   +1 more source

Breaking Free from Your Fetal Chains: A Case-Based Review of the Literature on Gamma Chain Variant Hemoglobinopathies [PDF]

Neonatal Medicine, 2023
Methemoglobinemia is a dyshemoglobinemia characterized by cyanosis and reduced oxygen saturation with increased methemoglobin values. The etiology may be congenital or acquired, with the latter being more common.
Pearl Mary Varughese, Sajan Thomas, Sheela Nampoothiri, Perraju Bendapudi   +3 more
doaj   +1 more source

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Haematologica, 2020
Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of β-hemoglobinopathies such as sickle cell disease.
A. Gilmartin, Arthur Groy, Elizabeth R. Gore, C. Atkins, E. R. Long, M. Montoute, Zining Wu, Wendy S. Halsey, D. Mcnulty, D. Ennulat, Lourdes Rueda, M. Pappalardi, Ryan G. Kruger, M. McCabe, A. Raoof, R. Butlin, A. Stowell, Mark J. Cockerill, I. Waddell, D. Ogilvie, J. Luengo, A. Jordan, Andrew B. Benowitz   +22 more
semanticscholar   +1 more source

Fetal cells in maternal circulation : fetal cell separation and FISH analysis [PDF]

, 2005
This work focuses on the isolation of fetal cells from the blood of pregnant women, with the aim of developing safe, efficacious, non-invasive alternatives for prenatal diagnosis.
Babochkina, Tatiana Ivanovna
core   +1 more source

Structural and functional characterization of CSDA protein complexes involved in the modulation of fetal globin gene expression [PDF]

, 2009
Impaired switching from fetal hemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal hemoglobin (HPFH) in adult life.
Gaudino, Sara
core   +1 more source

Sickle cell disease and fetal hemoglobin

Saudi Journal of Medicine and Medical Sciences, 2018
Alicia Rivera
doaj   +3 more sources

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease

Haematologica, 2020
While ineffective erythropoiesis has long been recognized as a key contributor to anemia in thalassemia, its role in anemia of sickle cell disease (SCD) has not been critically explored.
Sara El Hoss, S. Cochet, A. Godard, Hongxia Yan, Michael Dussiot, G. Frati, B. Boutonnat-Faucher, S. Laurance, O. Renaud, L. Joseph, A. Miccio, V. Brousse, N. Mohandas, W. El Nemer   +13 more
semanticscholar   +1 more source

STUDY OF FETAL HEMOGLOBIN WITH GESTATIONAL AGE, BIRTH WEIGHT AND RETINOPATHY OF PREMATURITY IN PRETERM INFANTS

IJRETINA (International Journal of Retina), 2023
Introduction: The objective of this study was to find an association of fetal hemoglobin (HbF) with gestational age, birth weight and retinopathy of prematurity (ROP) in preterm infants. Methods: Observational prospective study. We included a total of
Nishi Prasad, Aditi Dubey, Kavita Kumar, Jyotsna Shrivastava   +3 more
doaj   +1 more source

Genome editing strategies for fetal hemoglobin induction in beta-hemoglobinopathies.

Human Molecular Genetics, 2020
Genome editing to correct a defective β-globin gene or induce fetal globin (HbF) for patients with beta-hemoglobinopathies has the potential to be a curative strategy available to all.
Selami Demirci, Alexis Leonard, J. Tisdale   +2 more
semanticscholar   +1 more source

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.

Blood Advances, 2019
Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic repeats/Cas9-mediated disruption of DNA regulatory elements that repress γ-globin gene (HBG1 and HBG2) expression is a promising therapeutic strategy for sickle ...
J. Métais, Phillip A. Doerfler, Thiyagaraj Mayuranathan, Daniel E. Bauer, Stephanie C. Fowler, Matthew M. Hsieh, Varun Katta, Sagar Keriwala, Cicera R. Lazzarotto, Kevin Luk, M. Neel, S. S. Perry, Samuel T. Peters, Shaina N. Porter, B. Ryu, Akshay Sharma, Devlin N. Shea, J. Tisdale, N. Uchida, Scot A. Wolfe, Kaitly J. Woodard, Yuxuan Wu, Yu Yao, Jing Zeng, Shondra M. Pruett-Miller, Shengdar Q. Tsai, M. Weiss   +26 more
semanticscholar   +1 more source