Results 81 to 90 of about 1,339,121 (337)

Fetal hemoglobin silencing in humans

Blood, 2006
AbstractInterruption of the normal fetal-to-adult transition of hemoglobin expression should largely ameliorate sickle cell and beta-thalassemia syndromes. Achievement of this clinical goal requires a robust understanding of gamma-globin gene and protein silencing during human development.
Patricia A, Oneal, Nicole M, Gantt, Joseph D, Schwartz, Natarajan V, Bhanu, Y Terry, Lee, John W, Moroney, Christopher H, Reed, Alan N, Schechter, Naomi L C, Luban, Jeffery L, Miller   +9 more
openaire   +3 more sources

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

Science, 2018
A CRISPR screen for RBC regulators Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin.
Jeremy D. Grevet, Xian-Jiang Lan, Nicole Hamagami, Christopher R. Edwards, Laavanya Sankaranarayanan, Xin-Jun Ji, Saurabh K. Bhardwaj, Carolyne J. Face, D. Posocco, O. Abdulmalik, C. Keller, B. Giardine, Simone Sidoli, B. A. Garcia, Stella T. Chou, S. Liebhaber, R. Hardison, Junwei Shi, G. Blobel   +18 more
semanticscholar   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Hereditary Persistence of Fetal Hemoglobin: A Benign Condition Causing Diagnostic Challenges in Hemoglobin Variants—A Case Report [PDF]

Indian Journal of Medical Biochemistry
Hereditary persistence of fetal hemoglobin (HPFH) is a rare genetic condition characterized by elevated levels of fetal hemoglobin (HbF) in adults due to β-globin gene cluster abnormalities.
Manthan Dhingra, Javed Ahmed Ansari, Dhiraj Kumar, Navjot Kaur, Abhra Ghosh   +4 more
doaj   +1 more source

Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major

Molecular Therapy: Methods & Clinical Development, 2018
In the present report, we carried out clinical-scale editing in adult mobilized CD34+ hematopoietic stem and progenitor cells (HSPCs) using zinc-finger nuclease-mediated disruption of BCL11a to upregulate the expression of γ-globin (fetal hemoglobin). In
N. Psatha, A. Reik, Susan R. Phelps, Yuanyue Zhou, D. Dalas, E. Yannaki, D. Levasseur, F. Urnov, M. Holmes, T. Papayannopoulou   +9 more
semanticscholar   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Índice cárdio-femoral para avaliação da anemia de fetos de gestantes isoimunizadas Cardiofemoral index for the evaluation of fetal anemia in isoimmunized pregnancies

Revista Brasileira de Ginecologia e Obstetrícia, 2005
OBJETIVO: estabelecer novo marcador não invasivo na detecção da anemia fetal, em gestantes isoimunizadas por antígenos eritrocitários. MÉTODOS: em estudo transversal o índice ecográfico obtido pela razão entre a medida ecográfica do diâmetro ...
Antônio Carlos Vieira Cabral, Thales Bittencourt de Barcelos, Isabela Gomes Melo Apocalipse, Henrique Vitor Leite, Zilma Silveira Nogueira Reis   +4 more
doaj   +1 more source

KLF1 drives the expression of fetal hemoglobin in British HPFH.

Blood, 2017
β-Hemoglobinopathies are among the most common single-locus inherited diseases. In this condition, high fetal hemoglobin (HbF) levels have been found to be beneficial, and boosting HbF expression is seen as an attractive therapy.
B. Wienert, Gabriella E Martyn, R. Kurita, Yukio Nakamura, K. Quinlan, M. Crossley   +5 more
semanticscholar   +1 more source

The primary structure of three hemoglobin chains from the indigo snake (Drymarchon corais erebennus, Serpentes): First evidence for αD chains and two β chain types in snakes [PDF]

, 2002
The hemoglobin of the indigo snake (Drymarchon corais erebennus, Colubrinae) consists of two components, HbA and HbD, in the ratio of 1:1. They differ in both their alpha and beta chains.
Kleinschmidt, T., Gorr, T., Stoeckelhuber, M.   +2 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source