Results 21 to 30 of about 72,054 (299)

High Levels Of Human γ-globin Are Expressed In Adult Mice Carrying A Transgene Of The Brazilian Type Of Hereditary Persistence Of Fetal Hemoglobin (aγ -195) [PDF]

, 2015
Hereditary persistence of fetal hemoglobin (HPFH) is characterized by increased levels of Hb F during adult life. Nondeletional forms of HPFH are characterized by single base mutations in the Aγ and Gγ promoters, resulting in an increase of Hb F ranging ...
Da Cunha A.F., Corra Passos L.A., Costa F.F., Gimenes A.P., Saad S.T.O., Brugnerotto A.F., Barbosa De Melo M., Finzi Corat M.A., Bodine D., Devlin E.E.   +9 more
core   +3 more sources

Fetomaternal hemorrhage - case report

Journal of Education, Health and Sport, 2022
Maternal fetal leakage (FMH) is a well-known cause of fetal anemia. We define it as the transition of the fetal erythrocytes into the maternal circulation. Its severity is determined by measuring the level of fetal hemoglobin in the mother's blood using
Jakub Gruszka, Anna Zwierzyńska, Magdalena Dolecka-Ślusarczyk, Olga Adamczyk-Gruszka   +3 more
doaj   +1 more source

Perspective: A novel prognostic for sickle cell disease

Saudi Journal of Medicine and Medical Sciences, 2018
Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski, Abdullah Al-Rubaish, Amein Al-Ali, Jose Romero   +3 more
doaj   +1 more source

Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outcome

Haematologica, 2019
Hematologic responses to hypomethylating agents are often delayed in patients with myelodysplastic syndrome or acute myeloid leukemia. Fetal hemoglobin is a potential novel bio-marker of response: recently, we demonstrated that a high fetal hemoglobin ...
Julia Stomper, Gabriele Ihorst, Stefan Suciu, Philipp N. Sander, Heiko Becker, Pierre W. Wijermans, Christoph Plass, Dieter Weichenhan, Emmanuel Bissé, Rainer Claus, Michael Lübbert   +10 more
doaj   +1 more source

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. [PDF]

, 2015
BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals,
Soka, Deogratius, Harvest Mariki, Menzel, Stephan, Jeffrey C Barrett, Mariki, Harvest, Helen Rooks, Bruno Mmbando, Menzel, Stephan; id_orcid, Mmbando, Bruno, Tarjinder Singh, Stephan Menzel, Barrett, Jeffrey C., Sharon E Cox, Singh, Tarjinder, Mtatiro, Siana N, Barrett, Jeffrey C, Thein, Swee Lay, Deogratius Soka, Swee Lay Thein, Julie Makani, Mtatiro, Siana N., Siana N Mtatiro, Cox, Sharon E, Rooks, Helen, Mgaya, Josephine, Makani, Julie, Josephine Mgaya, Cox, Sharon E.   +27 more
core   +1 more source

Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in β0-thalassemia/HbE erythroid cells.

PLoS ONE, 2023
Imbalanced globin chain output contributes to thalassemia pathophysiology. Hence, induction of fetal hemoglobin in β-thalassemia and other β-hemoglobinopathies are of continuing interest for therapeutic approaches.
Sukanya Chumchuen, Orapan Sripichai, Natee Jearawiriyapaisarn, Suthat Fucharoen, Chayanon Peerapittayamongkol   +4 more
doaj   +1 more source

Flowcytometric assessment of fetomaternal hemorrhage during external cephalic version at term [PDF]

, 2008
External cephalic version (ECV) at term is a safe procedure and reduces the incidence of cesarean sections for breech presentation. One of the known complications, however, is an ECV-related disruption of the placental barrier and a subsequent ...
Toth, Bettina, Scholz, Christoph, Klaus Friese, Weissenbacher, Tobias, Franz Kainer, Christoph Scholz, Hermann, Christine, Tobias Weissenbacher, Kachler, Andrea, Kainer, Franz, Andrea Kachler, Christine Hermann, Friese, Klaus, Bettina Toth   +13 more
core   +1 more source

The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]

, 1974
For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core   +1 more source

Hydroxyurea ameliorates mouse hypoxia through inducing embryonic hemoglobin

陆军军医大学学报, 2023
Objective To investigate the ameliorative effect and mechanism of hydroxyurea (HU) on hypoxia mice in a closed environment. Methods Sixty male C57BL/6J mice (6~8 weeks old, weighing 18~22 g) were randomly divided into normoxia control group (NC, n=10 ...
ZHOU Xiaoying, JIAO Li, CUI Yu, CUI Yu, LI Xiaoxu, YANG Yidong   +4 more
doaj   +1 more source

Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes: A Comparative Analysis of the Current Reference Values

Anemia, 2013
Objectives. To compare current criteria for severe fetal anemia diagnosis. Methodology. A cohort study analyzed 105 alloimmunized fetuses that underwent cordocentesis due to risk of anemia.
Zilma Silveira Nogueira Reis, Gabriel Costa Osanan, Tiago Lanfernini Ricardo Coelho, Cezar Alencar De Lima Rezende, Henrique Vitor Leite, Antônio Carlos Vieira Cabral   +5 more
doaj   +1 more source