Results 11 to 20 of about 1,339,121 (337)

Transcriptional regulators of fetal hemoglobin [PDF]

Hematology, Transfusion and Cell Therapy
Sickle cell anemia is a hereditary disease caused by sickle-shaped red blood cells that can lead to vaso-occlusive crises. Treatment options are currently limited, highlighting the need to develop new clinical approaches.
Gabriela Pereira dos Santos, Larissa Teodoro Rabi, André Alves Bezerra, Marcelo Rodrigues da Cunha, Amilton Iatecola, Victor Augusto Ramos Fernandes   +5 more
doaj   +5 more sources

Oxidative stress in preeclampsia and the role of free fetal hemoglobin

Frontiers in Physiology, 2015
Preeclampsia is a leading cause of pregnancy complications and affects 3–7 % of pregnant women. This review summarizes the current knowledge of a new potential etiology of the disease, with a special focus on hemoglobin-induced oxidative stress ...
Asa Nääv, Stefan R Hansson, Lena Erlandsson   +2 more
exaly   +4 more sources

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

eLife, 2022
Naturally occurring point mutations in the HBG promoter switch hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary persistence of fetal hemoglobin (HPFH) and ameliorate the clinical severity.
Nithin Sam Ravi, Beeke Wienert, Stacia K Wyman, Henry William Bell, Anila George, Gokulnath Mahalingam, Jonathan T Vu, Kirti Prasad, Bhanu Prasad Bandlamudi, Nivedhitha Devaraju, Vignesh Rajendiran, Nazar Syedbasha, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Muthuraman Narayanasamy, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R Velayudhan, Alok Srivastava, Mark A DeWitt, Merlin Crossley, Jacob E Corn, Kumarasamypet M Mohankumar   +24 more
doaj   +2 more sources

Hereditary persistence of fetal hemoglobin

Asian Journal of Transfusion Science, 2020
Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.
Dharmesh Chandra Sharma, Sachin Singhal, Poonam Woike, Sunita Rai, Mahesh Yadav, Rajesh Gaur   +5 more
doaj   +3 more sources

Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outcome

Haematologica, 2019
Hematologic responses to hypomethylating agents are often delayed in patients with myelodysplastic syndrome or acute myeloid leukemia. Fetal hemoglobin is a potential novel bio-marker of response: recently, we demonstrated that a high fetal hemoglobin ...
Julia Stomper, Gabriele Ihorst, Stefan Suciu, Philipp N. Sander, Heiko Becker, Pierre W. Wijermans, Christoph Plass, Dieter Weichenhan, Emmanuel Bissé, Rainer Claus, Michael Lübbert   +10 more
doaj   +2 more sources

TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction

Molecular Therapy: Methods & Clinical Development, 2019
Elements within the γ-hemoglobin promoters (HBG1 and HBG2) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in the HBG1 promoter exhibit a clinically
Christopher T. Lux, Sowmya Pattabhi, Mason Berger, Cynthia Nourigat, David A. Flowers, Olivier Negre, Olivier Humbert, Julia G. Yang, Calvin Lee, Kyle Jacoby, Irwin Bernstein, Hans-Peter Kiem, Andrew Scharenberg, David J. Rawlings   +13 more
doaj   +2 more sources

Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes

Journal of Clinical Medicine, 2020
Fetal hemoglobin (HbF) usually consists of 4 to 10% of total hemoglobin in adults of African descent with sickle cell anemia. Rarely, their HbF levels reach more than 30%.

exaly   +2 more sources

Unexpected absence of fetal hemoglobin induction by lenalidomide in a patient with sickle cell anemia with concurrent multiple myeloma [PDF]

Orphanet Journal of Rare Diseases
Sickle cell anemia (SCA) and multiple myeloma (MM) are debilitating hematologic diseases impacting hemoglobin and plasma cells, respectively. Despite differing origins, they share overlapping clinical features including bone pain and anemia.
Rasmus Rønnemoes, Jens Helby, Amina Nardo-Marino, Morten Hanefeld Dziegiel, Jesper Petersen, Agoston Gyula Szabo, Nina Toft, Andreas Glenthøj   +7 more
doaj   +2 more sources

Fetal Hemoglobin Induction by Epigenetic Drugs

Seminars in Hematology, 2018
Fetal hemoglobin (HbF) inhibits the root cause of sickle pathophysiology, sickle hemoglobin polymerization. Individuals who naturally express high levels of HbF beyond infancy thus receive some protection from sickle complications.
James Engel, Donald Lavelle, Yogen Saunthararajah   +2 more
exaly   +2 more sources

The mRNA-Binding Protein IGF2BP1 Restores Fetal Hemoglobin in Cultured Erythroid Cells from Patients with β-Hemoglobin Disorders

Molecular Therapy: Methods & Clinical Development, 2020
Sickle cell disease (SCD) and β-thalassemia are caused by structural abnormality or inadequate production of adult hemoglobin (HbA, α2β2), respectively.
Christopher B. Chambers, Jeffrey Gross, Katherine Pratt, Xiang Guo, Colleen Byrnes, Y. Terry Lee, Donald Lavelle, Ann Dean, Jeffery L. Miller, Andrew Wilber   +9 more
doaj   +2 more sources