Transcriptional regulators of fetal hemoglobin [PDF]
Hematology, Transfusion and Cell TherapySickle cell anemia is a hereditary disease caused by sickle-shaped red blood cells that can lead to vaso-occlusive crises. Treatment options are currently limited, highlighting the need to develop new clinical approaches.
Gabriela Pereira dos Santos +5 more
doaj +5 more sources
A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds [PDF]
HemaSphereReactivation of fetal hemoglobin expression alleviates the symptoms associated with β‐globinopathies, severe hereditary diseases with significant global health implications due to their high morbidity and mortality rates.
Thijs C. J. Verheul +15 more
doaj +4 more sources
Hereditary persistence of fetal hemoglobin
Asian Journal of Transfusion Science, 2020 Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.
Dharmesh Chandra Sharma +5 more
doaj +3 more sources
Effect of hydroxyurea on G gamma chain fetal hemoglobin synthesis by sickle-cell disease patients [PDF]
Brazilian Journal of Medical and Biological Research, 2003 Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis and consequently decrease the severity of pain episodes.
S.M. Teixeira +2 more
doaj +5 more sources
Unexpected absence of fetal hemoglobin induction by lenalidomide in a patient with sickle cell anemia with concurrent multiple myeloma [PDF]
Orphanet Journal of Rare DiseasesSickle cell anemia (SCA) and multiple myeloma (MM) are debilitating hematologic diseases impacting hemoglobin and plasma cells, respectively. Despite differing origins, they share overlapping clinical features including bone pain and anemia.
Rasmus Rønnemoes +7 more
doaj +2 more sources
Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. [PDF]
PLoS ONE, 2013 Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease,
Nancy S Green +12 more
doaj +4 more sources
The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis) [PDF]
Haematologica, 2016 Increased fetal hemoglobin levels lessen the severity of symptoms and increase the lifespan of patients with sickle cell disease. Hydroxyurea, the only drug currently approved for the treatment of sickle cell disease, is not effective in a large ...
Angela Rivers +9 more
doaj +3 more sources
Gene Expression Analysis Of The Brazilian Type Of Hereditary Persistence Of Fetal Hemoglobin: Identification Of Genes That Could Be Related To γ-globin Activation [PDF]
, 2015 Increased γ-globin production and consequent fetal hemoglobin (Hb F, α2γ2) formation is an important modulator of the clinical and hematological features of hemolytic anemias, such as sickle cell disease and β-thalassemia (β-thal).
Roversi F.M. +8 more
core +5 more sources
The Clinical Approach toward Hereditary Persistence of Fetal Hemoglobin: A Case Report
Iranian Journal of Allergy, Asthma and Immunology, 2022 Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin.
Afshin Ghaderi +3 more
doaj +1 more source
Is fetal middle cerebral artery peak systolic velocity correlated with hemoglobin levels in cases of nonimmune fetal anemia? [PDF]
, 2022 Objectives: To establish whether a correlation exists between the fetal middle cerebral artery peak systolic velocity (MCA PSV) and fetal hemoglobin levels before intrauterine transfusion (IUT) in cases of severe fetal anemia. Methods: This was a single-
Hye-Sung Won +6 more
core +1 more source