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Gene Therapy For Beta-Thalassemia: Updated Perspectives
The Application of Clinical Genetics, 2019 Allogeneic hematopoietic stem cell transplantation was until very recently, the only permanent curative option available for patients suffering from transfusion-dependent beta-thalassemia.
Garyfalia Karponi, Nikolaos Zogas
semanticscholar +1 more source
, 2023 Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. Three main forms have been described: thalassemia major, thalassemia intermedia, and thalassemia minor.
Oshiokhayamhe, Iyevhobu, Kenneth +6 more
openaire +2 more sources
Early Screening of Hemoglobinopathy in Indonesia Using Erythrocyte Indices [PDF]
, 2017 BACKGROUND: The mutation spectrums of hemoglobinopathy are different among populations that yield a different result of erythrocyte indices. Calculation of erythrocyte indices with some formula has been reported to differentiate between hemoglobinopathy ...
Rositawati, W. (Wiwik) +3 more
core +3 more sources
Korean Journal of Family Medicine, 2018 Background Considering the high prevalence of depression and anxiety among thalassemia patients and the role of social support in preventing mental disorders, this study aimed to determine prevalence of depression, anxiety, and perceived social support ...
A. Maheri +5 more
semanticscholar +1 more source
Stem cell research & therapeutics, 2018 BackgroundThalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy.
Methichit Wattanapanitch +8 more
semanticscholar +1 more source
Hospitalization causes due to iron overload in beta-Thalassemia in Gorgan, Iran [PDF]
, 2011 Objective: To evaluate causes of hospitalization (due to complications of iron overload and other causes) in beta-Thalassemic patients. Methodology: This study was performed on 244 patients with major beta-Thalassemia admitted in Taleghani hospital of ...
Jahazi, A. +2 more
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Biotechnology and Bioengineering, EarlyView.ABSTRACT Plasma transferrin (Tf) is the transport protein central to the process of iron recycling and metabolism. Holo‐Tf serves as the body's pool of ferric iron, facilitating transport from tissues such as the intestine, liver, spleen, and finally bone marrow, where iron is incorporated into erythropoiesis.
Shuwei Lu +9 more
wiley +1 more source
Iraqi Journal of Hematology, 2021 BACKGROUND: Iron deficiency is not common in thalassemia minor and nontransfusion dependent hemoglobinophaties. The majority of these patients have normal-to-high serum ferritin. OBJECTIVES: The aims of the study were to evaluate serum ferritin levels in
Mehdi Dehghani +4 more
doaj +1 more source
Genetic Study for Identifying Beta Thalassemia Trait in Relatives of Children with Beta Thalassemia Major. [PDF]
CureusThe most common inherited illness, thalassemia, is thought to have a detrimental effect on public health, particularly in endemic areas. Children with beta thalassemia disease have several mutations. Prevention and premarital examination are still the most effective measures to lessen the burden of beta thalassemia.This study primarily aimed to ...
Elasheer OM +5 more
europepmc +3 more sources
Effect of zinc supplementation on serum mlondealdehyde and lipid profiles on beta thalassemia major patients [PDF]
, 2012 Objectives: Thalassemic patients are seriously at risk of serum dislipidemia, zinc deficiency and tissue damage due to oxidative stress induced by iron storage.
Aboomardani, M. +3 more
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