Results 81 to 90 of about 30,419 (262)

Rare Co-occurrence of Beta-Thalassemia and Pseudoxanthoma elasticum: Novel Biomolecular Findings [PDF]

, 2020
A number of beta-thalassemia patients, independently from the type of beta-thalassemia (β0 or β+) and blood transfusion requirements, may develop, after puberty, dermal, cardiovascular, and ocular complications associated with an ectopic mineralization ...
Boraldi F., Costa S., Lofaro F. D., Moscarelli P., Quaglino D.   +4 more
core   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

Beta Thalassemia: An Overview of Epidemiology, Clinical Features, Diagnosis, and Management [PDF]

پزشکی بالینی ابن سینا
Background and Objective: Thalassemia is an inherited blood disorder with an autosomal recessive inheritance pattern caused by the reduced or absent production of globin chains.
Ghasem Miri-Aliabad
doaj  

Oral Aphthous-like Ulcers Response to Topical Therapy in Young Adult Woman with Beta-Thalassemia Intermedia [PDF]

Background: Beta thalassemia may have some oral manifestations. Oral mucosa ulcer may be one of the oral manifestations of beta-thalassemia. The oral ulcer may resemble recurrent aphthous stomatitis (RAS).
Dewi, Rona Tirtaardi, Hardianti, Mardiah Suci, Susanto, Hendri   +2 more
core   +2 more sources

Mutation analysis of β-thalassemia in East-Western Indian population: a recent molecular approach

The Application of Clinical Genetics, 2017
Parth S Shah,1 Nidhi D Shah,2 Hari Shankar P Ray,3 Nikunj B Khatri,3 Ketan K Vaghasia,3 Rutvik J Raval,4 Sandip C Shah,3 Mandava V Rao5 1Department of Medicine, Lahey Hospital and Medical Center, Boston, MA, 2Department of Pediatrics, Nassau University ...
Shah PS, Shah ND, Ray HSP, Khatri NB, Vaghasia KK, Raval RJ, Shah SC, Rao MV   +7 more
doaj  

Economic burden of sickle cell disease in Australia

Internal Medicine Journal, EarlyView.
Abstract Background Sickle cell disease (SCD) is an inherited condition that impairs red blood cell function, posing a substantial health burden on patients. As the prevalence of SCD in Australia rises due to migration, discussions surrounding treatment and management strategies are becoming more prominent. Aims Australia lacks a dedicated study on the
Steve Nwokeocha, Helen E. Haysom, Cameron Wellard, Tracy Roberts, Mwayi Kachapila, Melissa Chee, Dennis Petrie, Zoe K. McQuilten, Neil Waters, Anthea Greenway, Kylie Mason, Anna Nelson, Zane Kaplan, P. Joy Ho, Erica M. Wood, Adam Irving, on behalf of the Australian Haemoglobinopathy Registry   +16 more
wiley   +1 more source

Evaluation of Fractal and Radiomorphometric Measurements of Mandibular Bone Structure in Pediatric Patients With Molar Incisor Hypomineralization

International Journal of Paediatric Dentistry, EarlyView.
ABSTRACT Background Molar incisor hypomineralization (MIH) is associated with enamel's existing qualitative developmental defects. Aim This study aimed to assess the cortical and trabecular mandibular bone morphology in pediatric patients with MIH using fractal analysis (FA) and digital panoramic radiography (DPR) with various radiomorphometric indices.
Asli Soğukpinar Önsüren, Katibe Tugce Temur   +1 more
wiley   +1 more source

Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]

, 2017
Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Chondrou, Vasiliki, Kolovos, Petros, Sgourou, Argyro, Kourakli, Alexandra, Pavlidaki, Alexia, Kastrinou, Vlasia, John, Anne, Symeonidis, Argiris, Ali, Bassam R., Papachatzopoulou, Adamantia, Katsila, Theodora, Patrinos, George P.   +11 more
core   +4 more sources

Impacts of a Homestead Food Production Intervention on Anaemia and Micronutrient Deficiencies Among Women and Children in Rural Bangladesh: A Cluster‐Randomized Controlled Trial

Maternal &Child Nutrition, EarlyView.
The Food and Agricultural Approaches to Reducing Malnutrition (FAARM) trial found no evidence that a 3‐year Homestead Food Production intervention reduced anaemia or micronutrient deficiencies among women and young children in rural Bangladesh. The intervention had improved diets and hygiene practices, but bigger changes may be needed.
Amanda S. Wendt, Jillian L. Waid, Anna A. Müller‐Hauser, Nathalie J. Lambrecht, Tarique Md. Nurul Huda, Nicholas N. A. Kyei, Sabine Gabrysch   +6 more
wiley   +1 more source

Approaches to Management of Beta-Thalassemia Intermedia

Thalassemia Reports, 2013
Thalassemia intermedia is a genetically diverse group of diseases that is the result of an imbalance in the production of the alpha and beta chains with ensuing chronic hemolysis, ineffective erythropoiesis, and iron overload.Resulting complications include bone changes, hypercoagulability, and end-organ damage due to iron overload.
Maakaron, Joseph E., Taher, Ali T.
openaire   +4 more sources