Results 61 to 70 of about 1,636,711 (267)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Marine Forecasting Systems in Caspian Sea, Persian Gulf and Oman Sea

International Journal of Coastal and Offshore Engineering, 2016
There are several global marine forecast systems based on large scale regional data covering Iranian seas which are freely available on their websites. They are also several local marine forecast systems in Iranian waters.
Aliasghar Golshani, Alireza Vaselali, Said Mazaheri   +2 more
doaj  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Partial Niche Partitioning in Three Sympatric Gull Species Through Foraging Areas and Habitat Selection

Ecology and Evolution
Anthropogenic habitat change is having a detrimental impact on biodiversity worldwide, altering the foraging behaviour and population dynamics of many species.
Nina J. O'Hanlon, Gary D. Clewley, Daniel T. Johnston, Chris B. Thaxter, Samuel Langlois Lopez, Lucy R. Quinn, Philipp H. Boersch‐Supan, Elizabeth A. Masden, Francis Daunt, Jared Wilson, Niall H. K. Burton, Elizabeth M. Humphreys   +11 more
doaj   +1 more source

Developing a national programme of flood risk management measures: Moldova

E3S Web of Conferences, 2016
A Technical Assistance project funded by the European Investment Bank has been undertaken to develop a programme of flood risk management measures for Moldova that will address the main shortcomings in the present flood management system, and provide the
Ramsbottom David, Frank Enrico, Weisgerber Alain, Beros Marco   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Biofertilization increases soil organic carbon concentrations: results of a meta-analysis

International Journal of Agricultural Sustainability
Protecting and building soil carbon has become a global policy priority, and novel agronomic fertilization practices may contribute to soil protection and climate-smart agriculture.
Berta Singla Just, Evan Alexander Netherton Marks, Laura Roquer-Beni, Laia Llenas, Sergio Ponsà, Rosa Vilaplana   +5 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source