Results 61 to 70 of about 4,107,211 (292)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Prospective impacts of windstorm risk on carbon sinks and the forestry sector: an integrated assessment with Monte Carlo simulations

Environmental Research Letters
Storms pose a significant threat to economic activities in the forest sector and introduce non-permanence risks for carbon stocks. Following escalating climate ambitions, understanding and addressing these risks becomes imperative.
Félix Bastit, Miguel Riviere, Antonello Lobianco, Philippe Delacote   +3 more
doaj   +1 more source

Beta-Creaming

SSRN Electronic Journal, 2015
This paper considers sampling proportional to expected size from a partly unknown distribution. The applied context is the exploration for undiscovered resources, like oil accumulations in different deposits, where the most promising deposits are likely to be drilled first, based on some geologic size indicators (“creaming”). A size distribution within
Lillestøl, Jostein, Sinding-Larsen, Richard   +1 more
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Earnings beta

Review of Accounting Studies, 2020
AbstractThe literature on cash flow or earnings beta is theoretically well-motivated in its use of fundamentals, instead of returns, to measure systematic risk. However, empirical measures of earnings beta based on either log-linearizing the return equation or log-linearizing the clean-surplus accounting identity are often difficult to construct.
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Bromodomain Protein Inhibition Protects β-Cells from Cytokine-Induced Death and Dysfunction via Antagonism of NF-κB Pathway

Cells
Cytokine-induced β-cell apoptosis is a major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding its underlying mechanisms, few drugs have been translated to protect β-cells in T1D.
Vinny Negi, Jeongkyung Lee, Varun Mandi, Joseph Danvers, Ruya Liu, Eliana M. Perez-Garcia, Feng Li, Rajaganapati Jagannathan, Ping Yang, Domenic Filingeri, Amit Kumar, Ke Ma, Mousumi Moulik, Vijay K. Yechoor   +13 more
doaj   +1 more source

Theory of open quantum dynamics with hybrid noise

New Journal of Physics, 2018
We develop a theory to describe dynamics of a non-stationary open quantum system interacting with a hybrid environment, which includes high-frequency and low-frequency noise components. One part of the system–bath interaction is treated in a perturbative
Anatoly Yu Smirnov, Mohammad H Amin
doaj   +1 more source

Implementasi Openbravo pada Proses Transaksi Penjualan, Produksi dan Sistem Inventory (Studi Kasus PT. NUSANTARA BETA FARMA)

Jurnal Teknologi dan Sistem Informasi, 2015
PT. Beta Farma Nusantara (NBF) is a company that produces and sales of drugs and cosmetics. NBF has 1 factory and many administrative offices that located in many big cities in Indoenesia.
Fajril Akbar, Ricky Akbar, Mardaleni ., Netti .   +3 more
doaj   +1 more source