Results 101 to 110 of about 88,568 (304)
Frontiers in Physiology, 2017 Chronic stress induces endocrine disturbance, which contributes to the development of polycystic ovary syndrome (PCOS), a condition that remains a challenge for clinicians to cope with.
Hao-Yu Sun +28 more
doaj +1 more source
Reciprocal regulation of PKA and rac signaling [PDF]
, 2013 Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml +47 more
core +1 more source
Journal of Biological Chemistry, 1996 The beta-adrenergic receptor kinase (beta ARK) modulates beta-adrenergic and other G protein-coupled receptors by rapidly phosphorylating agonist-occupied receptors at the plasma membrane.
C. Murga +5 more
semanticscholar +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
The Effect of Atenolol on CK-MB Levels in Hypertensive Patients
Iraqi Journal of Pharmaceutical Sciences, 2017 Atenolol is one of beta-adrenergic receptor blocking agent. It is widely used for the treatment of hypertension as a selective antihypertensive drug. But long term usage of atenolol may cause one of the cardiovascular diseases like myocardial infarction.
Inaam A. Amin
doaj +3 more sources
Contribution of the sympathetic nervous system to the pathogenesis of salt-sensitive hypertension [PDF]
, 2016 Dysregulation of the sodium-chloride cotransporter (NCC) is believed to significantly impact blood pressure. Recent studies have implicated overactivity of the sympathetic nervous system as a mechanism driving renal NCC dysregulation to evoke the ...
Pazzol, Michael Lee
core +1 more source
High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. [PDF]
, 2017 Key pointsPatients with diabetes show a blunted cardiac inotropic response to β-adrenergic stimulation despite normal cardiac contractile reserve. Acute insulin stimulation impairs β-adrenergically induced contractile function in isolated cardiomyocytes ...
Chiamvimonvat, Nipavan +8 more
core +2 more sources
Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition
Chemistry &Biodiversity, EarlyView.ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi +7 more
wiley +1 more source
Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.
PLoS ONE, 2010 With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Sarah Auburn +14 more
doaj +1 more source
Physiological Reports, 2022 Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1).
Kyle D. Medak +4 more
doaj +1 more source