Results 91 to 100 of about 26,478 (271)

The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection [PDF]

, 2009
The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, Laurice V, Fretwell, LV
core  

The Effect of Atenolol on CK-MB Levels in Hypertensive Patients

Iraqi Journal of Pharmaceutical Sciences, 2017
Atenolol is one of beta-adrenergic receptor blocking agent. It is widely used for the treatment of hypertension as a selective antihypertensive drug. But long term usage of atenolol may cause one of the cardiovascular diseases like myocardial infarction.
Inaam A. Amin
doaj   +3 more sources

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.

PLoS ONE, 2010
With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Sarah Auburn, Andrew E Fry, Taane G Clark, Susana Campino, Mahamadou Diakite, Angela Green, Anna Richardson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Malcolm E Molyneux, Terrie E Taylor, Kasturi Haldar, Kirk A Rockett, Dominic P Kwiatkowski   +14 more
doaj   +1 more source

The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued by cilostamide

Physiological Reports, 2022
Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1).
Kyle D. Medak, Greg L. McKie, Hesham Shamshoum, Ian Seguin, David C. Wright   +4 more
doaj   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Adverse effects on beta-adrenergic receptor coupling: ischemic postconditioning failed to preserve long-term cardiac function [PDF]

, 2017
BACKGROUND: Ischemic preconditioning (IPC) and ischemic postconditioning (IPoC) are currently among the most efficient strategies protecting the heart against ischemia/reperfusion injury.
Schlüter Klaus-Dieter, Schulz Rainer, Bencsik, Péter, Abdallah Y, Y., Péter Bencsik, Yaser Abdallah, Kamilla Gömöri, Judit Pipis, Bencsik Péter, Weber Martin, Gömöri, Kamilla, Kiss Krisztina, Abdallah Yaser, Schreckenberg R, Schulz R, Rainer Schulz, Csonka Csaba, Weber M, Csaba Csonka, Schreckenberg Rolf, Pálóczi János, Márta Sárközy, Abdallah Y, Pálóczi, János, Rolf Schreckenberg, Weber M, M., Kiss, Krisztina, Krisztina Kiss, Péter Ferdinandy, Pipis J, Pipis Judit, Sárközy Márta, Gömöri Kamilla, Ferdinandy, Péter, Martin Weber, Klaus‐Dieter Schlüter, Ferdinandy Péter, Csonka, Csaba, Sárközy, Márta, János Pálóczi, Schreckenberg R, R., Schluter KD   +41 more
core   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Ginsenoside Rb1 Induces Beta 3 Adrenergic Receptor–Dependent Lipolysis and Thermogenesis in 3T3-L1 Adipocytes and db/db Mice

Frontiers in Pharmacology, 2019
Obesity is constantly rising into a major health threat worldwide. Activation of brown-like transdifferentiation of white adipocytes (browning) has been proposed as a promising molecular target for obesity treatment.
Seona Lim, Seona Lim, Jinbong Park, Jinbong Park, Jae-Young Um, Jae-Young Um, Jae-Young Um   +6 more
doaj   +1 more source

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

Journal of Biological Chemistry, 1991
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Structural features of this enzyme have been elucidated recently by the isolation of a cDNA that encodes bovine beta ARK.
J L, Benovic, J J, Onorato, J L, Arriza, W C, Stone, M, Lohse, N A, Jenkins, D J, Gilbert, N G, Copeland, M G, Caron, R J, Lefkowitz   +9 more
openaire   +2 more sources

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. [PDF]

, 1998
BACKGROUND: Impaired myocardial beta-adrenergic receptor (betaAR) signaling, including desensitization and functional uncoupling, is a characteristic of congestive heart failure.
Tomhave, ED, R. J. Lefkowitz, Lefkowitz, RJ, IACCARINO, Guido, W. J. Koch, Tomhave, E. D., Iaccarino, G, Lefkowitz, R. J., Koch, W. J., E. D. Tomhave, Koch, WJ   +10 more
core   +1 more source