Results 71 to 80 of about 26,478 (271)

Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. [PDF]

, 1999
Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1, which phosphorylates and desensitizes beta-adrenergic receptors. In this study,
R. J. Lefkowitz, Koch, Walter J, W. J. Koch, Iaccarino, Guido, Dolber, Paul Christian, Lefkowitz, Robert J, P. C. Dolber, G. Iaccarino   +7 more
core  

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Coupling of alpha(1)-Adrenoceptors to ERK1/2 in the Human Prostate [PDF]

, 2011
Introduction: alpha(1)-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further alpha(1)-adrenoceptor functions besides contraction.
Goettinger, Johanna, Martin Hennenberg, Christian G. Stief, Petter Hedlund, Göttinger, Johanna,, Stief, Christian G., Christian Gratzke, Andersson, Karl-Erik, Reich, Oliver,, Reich, Oliver, Johanna Göttinger, Stief, Christian G.,, Schlenker, Boris,, Bauer, Ricarda M.,, Hedlund, Petter,, Andersson, Karl-Erik,, Strittmatter, Frank, Hennenberg, Martin,, Bauer, Ricarda M., Oliver Reich, Gratzke, Christian,, Ricarda M. Bauer, Hedlund, Petter, Frank Strittmatter, Karl-Erik Andersson, Gratzke, Christian, Hennenberg, Martin, Strittmatter, Frank,, Schlenker, Boris, Boris Schlenker   +29 more
core   +1 more source

Association of the ADRB2 rs1042714 variant with retinopathy of prematurity highlights the importance of the renin-angiotensin-aldosterone system

Scientific Reports
Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness globally. The clinical progression of ROP exhibits notable similarities to infantile hemangioma (IH), suggesting shared risk factors and underlying mechanisms.
Anna Chmielarz-Czarnocińska, Anna Durska, Bartosz Skulimowski, Alicja Sobaniec, Anna Gotz-Więckowska, Ewa Strauss   +5 more
doaj   +1 more source

Crosstalk between beta‐adrenergic and insulin signaling mediates mechanistic target of rapamycin hyperactivation in liver of high‐fat diet‐fed male mice

Physiological Reports, 2021
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. While increased nutrient intake and sympathetic activity have been associated with the disease, the pathogenesis of NAFLD remains incompletely understood.
Sadia Ashraf, Nadia Ashraf, Gizem Yilmaz, Romain Harmancey   +3 more
doaj   +1 more source

Structure of the human gene encoding the beta-adrenergic receptor kinase.

Journal of Biological Chemistry, 1994
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the agonist-occupied forms of the beta 2-adrenergic receptor and related G protein-coupled receptors. beta ARK is one of the best characterized members of a growing family of G protein-coupled receptor kinases.
R B, Penn, J L, Benovic
openaire   +2 more sources

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]

, 2004
The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Lin, J., Jaeger, S., Tempst, P., Puigserver, P., Fan, M., Handschin, C., St-Pierre, J., Spiegelman, B. M., Rhee, J., Erdjument-Bromage, H.   +9 more
core   +1 more source

Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptor

Communications Biology
The receptor tyrosine kinase EphA2 drives cancer malignancy by facilitating metastasis. EphA2 can be found in different self-assembly states: as a monomer, dimer, and oligomer.
Ryan J. Schuck, Alyssa E. Ward, Amita R. Sahoo, Jennifer A. Rybak, Robert J. Pyron, Thomas N. Trybala, Timothy B. Simmons, Joshua A. Baccile, Ioannis Sgouralis, Matthias Buck, Rajan Lamichhane, Francisco N. Barrera   +11 more
doaj   +1 more source

Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells

Archives of Medical Science, 2016
Introduction : It is a widely held view that a progressive reduction of beta-cell mass occurs in the progression of diabetes. RAF-1 kinase and pancreas duodenal homeobox 1 (PDX-1) are major factors that promote survival of cells and maintain normal ...
Sher Zaman Safi, Rajes Qvist, Gracie Ong, Hamed Karimian, Muhammad Imran, Ikram Shah   +5 more
doaj   +1 more source

α1A Adrenoreceptor blockade attenuates myocardial infarction by modulating the integrin-linked kinase/TGF-β/Smad signaling pathways

BMC Cardiovascular Disorders, 2023
Background Myocardial infarction (MI) is considered a public health problem. According to the World Health Organization, MI is a leading cause of death and comorbidities worldwide. Activation of the α1A adrenergic receptor is a contributing factor to the
Nawal M. Alrasheed, Raghad B. Alammari, Tahani K. Alshammari, Maha A. Alamin, Abeer O. Alharbi, Asma S. Alonazi, Anfal F. Bin Dayel, Nouf M. Alrasheed   +7 more
doaj   +1 more source