Results 1 to 10 of about 63,627 (120)

Role of β-adrenergic receptors in insulin resistance: Induction or protection?

Zagazig Journal of Pharmaceutical Sciences, 2021
β Adrenergic receptors, in particular β2 subtype, are key regulators of glucose homeostasis. Previous studies showed that activation of hepatic and adipose tissue β adrenergic receptors mediates insulin desensitizing effects.
Wael Ibrahim , Islam Ibrahim, Amr Mahmoud , Mona Abdelaziz   +3 more
doaj   +1 more source

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

Cell Reports, 2021
Summary: The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF21 co-
Mohammad Abu-Odeh, Yuan Zhang, Shannon M. Reilly, Nima Ebadat, Omer Keinan, Joseph M. Valentine, Maziar Hafezi-Bakhtiari, Hadeel Ashayer, Lana Mamoun, Xin Zhou, Jin Zhang, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Steven A. Kliewer, David J. Mangelsdorf, Alan R. Saltiel   +18 more
doaj   +1 more source

Implication of β2-adrenergic receptor and miR-196a correlation in neurite outgrowth of LNCaP prostate cancer cells.

PLoS ONE, 2021
The β2-adrenergic receptor has been shown to be involved in neuroendocrine differentiation and to contribute to the development of aggressive prostate cancer.
Ilaria Guerriero, Håkon Ramberg, Krizia Sagini, Manuel Ramirez-Garrastacho, Kristin A Taskén, Alicia Llorente   +5 more
doaj   +1 more source

β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. [PDF]

PLoS ONE, 2014
Autophagy recently has been shown to be involved in normal hepatic function and in pathological conditions such as non-alcoholic fatty liver disease. Adrenergic signalling also is an important regulator of hepatic metabolism and function.
Benjamin L Farah, Rohit A Sinha, Yajun Wu, Brijesh K Singh, Jin Zhou, Boon-Huat Bay, Paul M Yen   +6 more
doaj   +1 more source

β2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype. [PDF]

PLoS ONE, 2013
There is considerable evidence from our lab and others for a functional link between β-adrenergic receptor and insulin receptor signaling pathways in retina.
Youde Jiang, Qiuhua Zhang, Li Liu, Jie Tang, Timothy S Kern, Jena J Steinle   +5 more
doaj   +1 more source

Adverse Effects on β‐Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long‐Term Cardiac Function

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundIschemic preconditioning (IPC) and ischemic postconditioning (IPoC) are currently among the most efficient strategies protecting the heart against ischemia/reperfusion injury. However, the effect of IPC and IPoC on functional recovery following
Rolf Schreckenberg, Péter Bencsik, Martin Weber, Yaser Abdallah, Csaba Csonka, Kamilla Gömöri, Krisztina Kiss, János Pálóczi, Judit Pipis, Márta Sárközy, Péter Ferdinandy, Rainer Schulz, Klaus‐Dieter Schlüter   +12 more
doaj   +1 more source

Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling. [PDF]

PLoS ONE, 2017
Adaptive thermogenesis and cold-induced activation of uncoupling protein 1 (Ucp1) in brown adipose tissue in rodents is well-described and attributed to sympathetic activation of β-adrenergic signaling.
Shannon H Carroll, Ellen Zhang, Bing F Wang, Katherine B LeClair, Arifeen Rahman, David E Cohen, Jorge Plutzky, Parth Patwari, Richard T Lee   +8 more
doaj   +1 more source

Differential regulations of vestibulo-ocular reflex and optokinetic response by β- and α2-adrenergic receptors in the cerebellar flocculus

Scientific Reports, 2017
Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and optokinetic ...
Ryo Wakita, Soshi Tanabe, Kazunari Tabei, Asako Funaki, Takuma Inoshita, Tomoo Hirano   +5 more
doaj   +1 more source

Caveolae-Independent Activation of Protein Kinase A in Rat Neonatal Myocytes

Journal of Pharmacological Sciences, 2005
Cardiomyocytes express both β1- and β2-adrenergic receptors, and these receptors play a differential role in chronotropic and inotropic effects of the heart. Caveolae are known as an important regulator of G-protein-coupled receptor signaling.
Masashi Fukutomi, Motohiro Nishida, Yoshiko Maruyama, Hiroyuki Kobayashi, Hitoshi Kurose   +4 more
doaj   +1 more source

Serum Activity Against G Protein–Coupled Receptors and Severity of Orthostatic Symptoms in Postural Orthostatic Tachycardia Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and orthostatic intolerance. Previous data indicate autoimmune involvement.
Isabella Kharraziha, Jonas Axelsson, Fabrizio Ricci, Giuseppe Di Martino, Margaretha Persson, Richard Sutton, Artur Fedorowski, Viktor Hamrefors   +7 more
doaj   +1 more source