Results 21 to 30 of about 2,121,152 (251)

Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Nature Communications, 2021
Early life trauma has been associated with multiple sclerosis, but the causal link is unclear. Here the authors show in mice that early life trauma can result in IFN-β-resistant EAE as a result of β-adrenergic desensitization in immune cells and that a ...
Yee Ming Khaw, Danish Majid, Sungjong Oh, Eunjoo Kang, Makoto Inoue   +4 more
doaj   +1 more source

Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?

Pharmaceuticals, 2015
Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect ...
Joseph Vamecq, Karine Mention-Mulliez, Francis Leclerc, Dries Dobbelaere   +3 more
doaj   +1 more source

Opposing effects of α2- and β-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis. [PDF]

PLoS ONE, 2014
Norepinephrine regulates latent neural stem cell activity and adult hippocampal neurogenesis, and has an important role in modulating hippocampal functions such as learning, memory and mood.
Dhanisha J Jhaveri, Ishira Nanavaty, Boris W Prosper, Swanand Marathe, Basma F A Husain, Steven G Kernie, Perry F Bartlett, Vidita A Vaidya   +7 more
doaj   +1 more source

Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains

Frontiers in Endocrinology, 2022
More than 12 years have passed since the seminal observation that meningococcus, a pathogen causing epidemic meningitis in humans, occasionally associated with infectious vasculitis and septic shock, can promote the translocation of β-arrestins to the ...
Stefano Marullo, Mark G. H. Scott, Hervé Enslen, Mathieu Coureuil   +3 more
doaj   +1 more source

Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart. [PDF]

PLoS ONE, 2011
BACKGROUND: Neuroendocrine activation and local mediators such as transforming growth factor-β₁ (TGF-β₁) contribute to the pathobiology of cardiac hypertrophy and failure, but the underlying mechanisms are incompletely understood.
Michael Huntgeburth, Klaus Tiemann, Robert Shahverdyan, Klaus-Dieter Schlüter, Rolf Schreckenberg, Marie-Luise Gross, Sonja Mödersheim, Evren Caglayan, Jochen Müller-Ehmsen, Alexander Ghanem, Marius Vantler, Wolfram H Zimmermann, Michael Böhm, Stephan Rosenkranz   +13 more
doaj   +1 more source

Enriched environment enhances β‐adrenergic signaling to prevent microglia inflammation by amyloid‐β

EMBO Molecular Medicine, 2018
Environmental enrichment (EE) is a rodent behavioral paradigm that can model the cognitive benefits to humans associated with intellectual activity and exercise.
Huixin Xu, Molly M Rajsombath, Pia Weikop, Dennis J Selkoe   +3 more
doaj   +1 more source

Role of protein kinase C in cAMP-dependent exocytosis in parotid acinar cells

Japanese Dental Science Review, 2009
It is well known that β-adrenergic receptor activation in parotid acinar cells results in increased intracellular cAMP levels, and consequently induces exocytotic amylase release.
Hiroshi Sugiya, Keitaro Satoh
doaj   +1 more source

Impact of R-Carvedilol on β2-Adrenergic Receptor-Mediated Spontaneous Calcium Release in Human Atrial Myocytes

Biomedicines, 2022
A hallmark of atrial fibrillation is an excess of spontaneous calcium release events, which can be mimicked by β1- or β2-adrenergic stimulation. Because β1-adrenergic receptor blockers (β1-blockers) are primarily used in clinical practice, we here ...
Sergi Casabella-Ramón, Verónica Jiménez-Sábado, Carmen Tarifa, Sandra Casellas, Tien Tina Lu, Paloma Izquierdo-Castro, Ignasi Gich, Marcel Jiménez, Antonino Ginel, José M. Guerra, S. R. Wayne Chen, Raul Benítez, Leif Hove-Madsen   +12 more
doaj   +1 more source

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]

, 2013
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Jackson, Edwin K., Blessing, CP, Tammy Liu, Liu, Tammy, Liu, T, Christopher P Blessing, Jackson Edwin K., Liu Tammy, Gul, R, Pulakat, Lakshmi, Pulakat, L, Murat Bastepe, Blessing, Christopher P., Edwin K Jackson, Catherine E Erickson, Rukhsana Gul, Bastepe Murat, Lakshmi Pulakat, Andresen Bradley T., Nguyen, J, Pulakat Lakshmi, Gul, Rukhsana, Andresen, Bradley T., Erickson, CE, Blessing Christopher P., Holowka, David, Nguyen Jenny, Bastepe, Murat, Jackson, EK, Andresen, BT, Gul Rukhsana, Jenny Nguyen, Erickson Catherine E., Bastepe, M, Erickson, Catherine E., Nguyen, Jenny, Bradley T Andresen   +36 more
core   +2 more sources

G protein receptor kinase type 2: A novel target in cardiovascular drug development [PDF]

Hospital Pharmacology, 2014
In spite of significant advancement in pharmacotherapy, heart failure remains one of the main causes of death worldwide. The existing treatment of heart failure prolongs life span by slowing down the pathological process but does not induce heart healing.
Vasić Marko S., Japundžić-Žigon Nina M.   +1 more
doaj   +1 more source