Results 131 to 140 of about 26,478 (271)

Novel ocular antihypertensive compounds in clinical trials

Clinical Ophthalmology, 2011
June Chen1, Stephen A Runyan1, Michael R Robinson21Department of Biological Sciences, 2Ophthalmology Clinical Research, Allergan, Inc, Irvine, CA, USAIntroduction: Glaucoma is a multifactorial disease characterized by progressive optic nerve injury and ...
Chen J, Runyan SA, Robinson MR
doaj  

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Examining the suitability of molecular and metabolomic-based techniques as tools for assessing the effects of pharmaceuticals in the aquatic environment [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Pharmaceuticals represent important and indispensable elements in modern society and their usage is considerable.
Eccles, Paul David
core  

Development of Researches on Mechanisms of Acupuncture Intervention in Improving Myocardial Ischemia by Balancing Interaction between β-adrenergic Receptor and Acetylcholinergic Receptor Signal Transduction Pathway of Myocardiocytes

针刺研究, 2016
The imbalance of autonomic nervous function after myocardial ischemia(MI)accelerates the development of ischemic myocardial injury.The beta-adrenergic receptor(β-AR)and muscarinic acetylcholine receptor(M-AChR)are the main receptor types of the ...
SHI Li, GAO Jun-hong, ZHAO Ji-ping, ZHU Bing, YU Xiao-chun, RONG Pei-jing   +5 more
doaj  

Cardiac autoantibodies promote a fibrotic transcriptome and reduced ventricular recovery in human myocarditis

Frontiers in Immunology
Myocarditis leads to dilated cardiomyopathy (DCM) with one-third failing to recover normal ejection fraction (EF 50%). Our previous studies have supported a Th17 autoimmune pathogenesis where IL17A and IL-6 are elevated in myocarditis patients who do not
Jennifer M. Myers, Clayton Sandel, Kathy Alvarez, Lori Garman, Lori Garman, Graham Wiley, Courtney Montgomery, Patrick Gaffney, Stavros Stavrakis, DeLisa Fairweather, Katelyn A. Bruno, Yan Daniel Zhao, Leslie T. Cooper, Madeleine W. Cunningham   +13 more
doaj   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. [PDF]

, 1993
We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document that subtype 2 of the beta-
Boekhoff, I, Breer, H, Lefkowitz, RJ, Schleicher, S, Arriza, J   +4 more
core  

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source