Results 161 to 170 of about 2,306,523 (240)

Multiscale model calibrated with a Bayesian algorithm predicts long-term outcomes of treatments for mitral valve regurgitation in animal models. [PDF]

Biomech Model Mechanobiol
Bracamonte JH, Watkins L, Saucerman JJ, Holmes JW.   +3 more
europepmc   +1 more source

Revising NHE‐1: From Cardiac Homeostasis to Heart Failure and Future Drug Development

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT NHE‐1 is a Na+/H+ exchanger that receives phosphorylation signals, binds calmodulin and responds to neurohormonal input from angiotensin II, endothelin‐1, and adrenergic pathways. In cardiac myocytes, NHE‐1 maintains pH homeostasis and couples to Na+/Ca2+ exchange and mitochondrial ion handling. During heart disease sustained activation drives
Vasileios Bouratzis, Nikoleta Douskou, Nikolaos P. Tzavellas, Yannis V. Simos, Petros Bozidis, Konstantinos I. Tsamis, Georgios S. Markopoulos, Dimitrios Peschos, Lampros Lakkas   +8 more
wiley   +1 more source

Unlocking the Hepatoprotective Potential of Urolithin A in High‐Fat Diet‐Induced MASLD: Integrated Role of Oxidative Stress, Inflammation, FXR/PPAR‐α, and Fibrotic Pathway

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT “Metabolic dysfunction–associated steatotic liver disease” (MASLD) is marked by hepatic steatosis, oxidative stress, inflammation, and fibrosis. Urolithin A (Uro A), a metabolite of ellagitannins, exhibits anti‐inflammatory, antioxidant, and metabolic regulatory activities.
Hamad Alsaykhan, Amany Mohamed Shalaby, Walaa Arafa Keshk, Shahd Saad El‐dien Kamel, Sulaiman Mohammed Alnasser, Mohammed Alorini, Fatima A. Jaber, Mohamed Ali Alabiad, Amr Mohamed Younes, Hanim Magdy Abdelnour   +9 more
wiley   +1 more source

Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology. [PDF]

Kinases Phosphatases
Dotson CR, Underwood L, Sato PY.
europepmc   +1 more source

Mechanistic Insights Into the Association Between Gut Microbiota Diversity and Atherosclerosis, Acute Coronary Syndrome, and Peripheral Arterial Disease Progression

Clinical Cardiology, Volume 49, Issue 9, September 2026.
Proposed gut‐vascular framework linking microbial ecology to atherosclerotic disease. Diet and related exposures shape dysbiosis or microbial resilience; resulting changes in SCFAs, TMAO, bile acids, and LPS may modulate endothelial function, immune activation, and platelet activity, contributing to atherosclerosis, ACS, and PAD.
Amr Ali Mohamed Abdelgawwad El‐Sehrawy, Usamah Sayed, Zarina Nasirova, Quvonch Tursunov, Omer Qutaiba B. Allela, Lara Asim Kzar, Rajashree Panigrahi, Neeraj Bainsal   +7 more
wiley   +1 more source

Beyond Pleasure: Unraveling the Multifaceted Role of Dopamine in Obesity and Metabolic Regulation. [PDF]

Curr Obes Rep
Yang S, Huang Z, Lu W, Wang W, Wu S, Wang Y, Huang L, Chen L, Chen R, Liang F.   +9 more
europepmc   +1 more source

Pragmatic Phenotype–Electrophysiology–Genomics Integration in Pediatric Congenital Myasthenic Syndromes: Insights From 36 Patients in a Single‐Center Study in China

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
In 36 Chinese pediatric CMS patients, integrated phenotype, RNS, and genomic assessment revealed marked genetic heterogeneity across 17 CMS‐associated genes and frequent VUS‐related uncertainty. Genotype‐informed therapy improved MG‐ADL scores, while CHAT‐CMS identified a high‐risk subgroup for early respiratory failure and mortality.
Liya Cui, Kaiyue Ma, Xiaona Fu, Lin Ge, Bingbing Jia, Wenna Ma, Lei Yang, Zhimei Liu, Junlan Lv, Wenmiao Xu, Lijuan Wang, Guangyuan Zhao, Jiuwei Li, Jie Wu, Quan Wang, Changhong Ding, Xiaotun Ren, Xinming Shen, Hui Xiong   +18 more
wiley   +1 more source

Muscle Loss Driven by Extracellular Signal-Regulated Kinase Suppression via β-Adrenergic Activation in High-Normal Catecholamine Status. [PDF]

Endocrinol Metab (Seoul)
Lee J, Kwak JY, Lee HY, Moon JS, Jang HJ, Nga HT, Nguyen TL, Abdillah AM, Kim J, Kim S, Yang YR, Lee JE, Yi HS.   +12 more
europepmc   +1 more source

The Role and Mechanism of Incretins in Gynaecologic Diseases

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
This review outlines the mechanisms of incretins in polycystic ovary syndrome, endometriosis and gynaecological cancers, highlighting the translational potential of incretin‐based therapies for metabolic‐associated gynaecological disorders. ABSTRACT Background Obesity is a major global public health concern closely linked to the development and ...
Jiayu Yan, Minyue Cao, Yan Ding, Yiqin Zhang, Yihan Sun, Genyi Jiang, Yanli Zhang, Luyao Kang, Xue Zhou, Jing Luo, Bilan Li   +10 more
wiley   +1 more source

Loss of caveolar A1 adenosine receptor signalling blunts anti-adrenergic control in heart failure. [PDF]

Cardiovasc Res
Mazzola M, Wang H, Lang D, Balycheva M, Bhogal N, Sanchez-Alonso JL, Diakonov I, Lucarelli C, Lai EC, Punjabi PP, Miragoli M, Faggian G, Glukhov AV, Gorelik J.   +13 more
europepmc   +1 more source