Results 191 to 200 of about 24,989 (236)

Seeking Novel Personalized and Sex-Specific Strategies for the Prevention and Treatment of Heart Failure Based on the Assessment of β1-Adrenergic Receptor Desensitization: The Contribution to the HEAL ITALIA Project. [PDF]

Curr Issues Mol Biol
Vona R, Cittadini C, Mattia G, Puglisi R, Ascione B, Gambardella L, Maccari S, Marano G, Matarrese P.   +8 more
europepmc   +1 more source

Effects of AMPK/PGC-1α on gluconeogenesis in skeletal muscle of animals under overwintering starvation and its molecular mechanism: review. [PDF]

Anim Biosci
Huang C, Cheng H, Wen B, Li W, Luo B, Wu D, Wang J, Hu S, Wu J.   +8 more
europepmc   +1 more source

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The β-adrenergic receptor kinase in heart failure

Journal of Molecular and Cellular Cardiology, 2003
Heart failure (HF) remains a significant and increasing cause of worldwide morbidity and mortality. HF is less a disease than a common clinical endpoint resulting from diverse, but often co-existing etiologies-including hypertension, coronary artery disease, and viral cardiomyopathy.
Jason A, Petrofski, Walter J, Koch
openaire   +2 more sources

Activation of β-Adrenergic Receptor Kinase During Myocardial Ischemia

Circulation Research, 1996
During myocardial ischemia, a local release of noradrenaline coincides with an increased density of β-adrenergic receptors. The functional activity of these receptors, however, is mainly determined by their state of phosphorylation. The β-adrenergic receptor kinase (βARK) specifically phosphorylates and thereby inactivates β-adrenergic receptors after ...
M, Ungerer, K, Kessebohm, K, Kronsbein, M J, Lohse, G, Richardt   +4 more
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Desensitization of the isolated .beta.2-adrenergic receptor by .beta.-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

Biochemistry, 1992
Exposure of beta 2-adrenergic receptors (beta 2ARs) to agonists causes a rapid desensitization of the receptor-stimulated adenylyl cyclase response. Phosphorylation of the beta 2AR by several distinct kinases plays an important role in this desensitization phenomenon.
J, Pitcher, M J, Lohse, J, Codina, M G, Caron, R J, Lefkowitz   +4 more
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Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase

Biochemistry, 1989
Previous studies have demonstrated that muscarinic cholinergic receptors (mAChR) become markedly phosphorylated when intact cardiac cells are stimulated with a muscarinic agonist. This process appears to be related to the process of receptor desensitization. However, the mechanism of agonist-induced phosphorylation of mAChR is not known.
M M, Kwatra, J L, Benovic, M G, Caron, R J, Lefkowitz, M M, Hosey   +4 more
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Protein kinase activity of phosphoinositide 3-kinase regulates β-adrenergic receptor endocytosis

Nature Cell Biology, 2005
Phosphoinositide 3-kinase (PI(3)K) is a unique enzyme characterized by both lipid and protein kinase activities. Here, we demonstrate a requirement for the protein kinase activity of PI(3)K in agonist-dependent beta-adrenergic receptor (betaAR) internalization.
Sathyamangla V, Naga Prasad, Arundathi, Jayatilleke, Aasakiran, Madamanchi, Howard A, Rockman   +3 more
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β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

Science, 1989
The β-adrenergic receptor kinase (β-ARK), which specifically phosphorylates only the agonist-occupied form of the β-adrenergic and closely related receptors, appears to be important in mediating rapid agonist-specific (homologous) desensitization.
Benovic JL, DE BLASI, ANTONIO, Stone WC, Caron MG, Lefkowitz RJ   +4 more
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