Results 201 to 210 of about 2,306,523 (240)

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, Volume 183, Issue 17, Page 5315-5335, September 2026.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Might modulation of the endocannabinoid system provide a potential dual therapeutic strategy for osteoporosis and depression? [PDF]

Gen Psychiatr
Wei P, Zhao P, Gu Z, Yang M, Karasik D, Cheung CL, Zheng H.   +6 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Cross-Talk Between Signaling and Transcriptional Networks Regulating Thermogenesis-Insights into Canonical and Non-Canonical Regulatory Pathways. [PDF]

Int J Mol Sci
Simka-Lampa K.
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, Volume 59, Issue 9, September 2026.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Regulation and clinical manifestations of gluconeogenesis dysfunction. [PDF]

NPJ Metab Health Dis
Bobok N.
europepmc   +1 more source

In Vitro Effects of Anaesthetic Compounds on a Panel of Solid Tumour Cell Lines—An Exploratory Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Anaesthetic agents are essential for surgical procedures, yet their potential role on tumour cell biology remains incompletely understood. Emerging evidence suggests that these compounds can act both as protumor and antitumor agents, influencing cellular processes such as proliferation, migration and cell death mechanisms.
Olga Grajdieru, Alexandru Cristian Sabo, Adrian Bogdan Tigu, Andrei Ivancuta, Cristian Silviu Moldovan, Andrada Uhl, Miruna Cristina Ungurenasu, Andrada‐Ioana Balmez, Ada Moisescu, Simina Pîrv, Madalina Nistor, Ximena‐Maria Muresan, Diana Cenariu, Ciprian Tomuleasa, Catalin Constantinescu   +14 more
wiley   +1 more source

Targeting Macrophage-Mediated Mechanisms in Sepsis-Induced Cardiomyopathy: From Pathophysiology to Therapeutic Strategies. [PDF]

J Inflamm Res
Wang J, Zhang J, Luo N, Zhou Z, Zhang Y, Guo K, Li R, Li C.   +7 more
europepmc   +1 more source

Altered Retinal Dopamine Homeostasis in Murine Models of Retinitis Pigmentosa

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
Dopamine is an important catecholamine chemical messenger in the light‐sensing retina of the eye, where it serves multiple modulatory functions related to vision. This research studied the changes in the retinal dopamine system in two mouse models (P23H and rd10) of retinitis pigmentosa, which is a disease group of inherited retinal diseases that lead ...
Katri Vainionpää, Eerik Lappalainen, Anna Nilsson, Ida Pavela, Tommi Torsti, Umair Seemab, Elina Mäkinen, Reza Shariatgorji, Per E. Andrén, Aaro Jalkanen, Markus M. Forsberg, Henri Leinonen   +11 more
wiley   +1 more source

Comparative anatomy and metabolic profiles of brown and white adipose tissue in humans. [PDF]

Front Endocrinol (Lausanne)
Villarreal J, Baranova A.
europepmc   +1 more source