Results 21 to 30 of about 57,900 (247)

Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis

Frontiers in Physiology, 2021
Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes ...
Chul-Hong Park, Jiyoung Moon, Minsung Park, Helia Cheng, Jisu Lee, Ji Suk Chang   +5 more
doaj   +1 more source

A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach

Biomolecules, 2021
Obesity is a low-grade systemic inflammatory disease involving adipocytokines. As though Anmyungambi decoction (AMGB) showed significant improvement on obesity in a clinical trial, the molecular mechanism of AMGB in obesity remains unknown. Therefore, we
Dongyeop Jang, Hayeong Jeong, Chang-Eop Kim, Jungtae Leem   +3 more
doaj   +1 more source

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

Proceedings of the National Academy of Sciences of the United States of America, 1991
W Lorenz, James Inglese, Krzysztof Palczewski, James J. Onorato, Marc G. Caron, Robert J. Lefkowitz   +5 more
openalex   +3 more sources

Involvement of the Catecholamine Pathway in Glioblastoma Development

Cells, 2021
Glioblastoma (GBM) is the most aggressive tumor of the central nervous system (CNS). The standard of care improves the overall survival of patients only by a few months. Explorations of new therapeutic targets related to molecular properties of the tumor
Zoltán Kraboth, Bela Kajtár, Bence Gálik, Attila Gyenesei, Attila Miseta, Bernadette Kalman   +5 more
doaj   +1 more source

Specific enhancement of beta-adrenergic receptor kinase activity by defined G-protein beta and gamma subunits.

Proceedings of the National Academy of Sciences of the United States of America, 1993
Sabine Müller, Mirko Hekman, Martin J. Lohse   +2 more
openalex   +3 more sources

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

Proceedings of the National Academy of Sciences of the United States of America, 1986
R. H. Strasser, Jeffrey Benovic, Marc G. Caron, Robert J. Lefkowitz   +3 more
openalex   +3 more sources

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. [PDF]

PLoS ONE, 2012
The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation.
Fortune F Shea, Jennie L Rowell, Yechaowei Li, Tien-Hsien Chang, Carlos E Alvarez   +4 more
doaj   +1 more source

Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background ADRB1 (adrenergic receptor beta 1) responds to neuroendocrine stimulations, which have great implications in hypertension. GRK2 (G protein‐coupled receptor kinase 2) is an essential regulator for many G protein‐coupled receptors and subsequent
Xuejing Sun, Mengli Zhou, Gaiyan Wen, Yun Huang, Junru Wu, Liping Peng, Weihong Jiang, Hong Yuan, Yao Lu, Jingjing Cai   +9 more
doaj   +1 more source

G-Protein Inwardly Rectifying Potassium Channel 1 (GIRK1) Knockdown Decreases Beta-Adrenergic, MAP Kinase and Akt Signaling in the MDA-MB-453 Breast Cancer Cell Line

Breast Cancer: Basic and Clinical Research, 2008
Previous data from our laboratory have indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in breast cancer cell lines and that these pathways ...
Michael W. Hance, Madhu S. Dhar, Howard K. Plummer III   +2 more
doaj   +2 more sources

Activation of the Thiazide-Sensitive Sodium-Chloride Cotransporter by Beta3-Adrenoreceptor in the Distal Convoluted Tubule

Frontiers in Physiology, 2021
We previously showed that the beta-3 adrenergic receptor (BAR3) is expressed in most segments of the nephron where its agonism promotes a potent antidiuretic effect.
Serena Milano, Monica Carmosino, Andrea Gerbino, Ilenia Saponara, Dominga Lapi, Massimo Dal Monte, Paola Bagnoli, Maria Svelto, Giuseppe Procino   +8 more
doaj   +1 more source