Results 21 to 30 of about 89,923 (320)

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. [PDF]

Proceedings of the National Academy of Sciences, 1989
Homologous (agonist-specific) desensitization of beta-adrenergic receptors (beta ARs) is accompanied by and appears to require phosphorylation of the receptors. We have recently described a novel protein kinase, beta AR kinase, which phosphorylates beta ARs in vitro in an agonist-dependent manner.
M. Lohse, R. Lefkowitz, M. Caron, J. Benovic   +3 more
semanticscholar   +4 more sources

Mechanism of beta-adrenergic receptor kinase activation by G proteins

Journal of Biological Chemistry, 1993
The beta-adrenergic receptor kinase (beta-ARK) specifically phosphorylates the activated form of various G protein-coupled receptors such as the beta 2-adrenergic receptor (beta 2-AR). Recently, G protein beta gamma subunits have been demonstrated to activate beta-ARK-mediated receptor phosphorylation.
C.M. Kim, Sarah Dion, Jeffrey Benovic
openalex   +4 more sources

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

Journal of Biological Chemistry, 1987
Desensitization of the beta-adrenergic receptor, a receptor which is coupled to the stimulation of adenylate cyclase, may be regulated via phosphorylation by a unique protein kinase. This recently discovered enzyme, known as the beta-adrenergic receptor kinase, only phosphorylates the agonist-occupied form of the beta-adrenergic receptor.
J.L. Benovic, John W. Regan, Hiroaki Matsui, Federico Mayor, Susanna Cotecchia, L.M. Fredrik Leeb-Lundberg, Marc G. Caron, Robert J. Lefkowitz   +7 more
openalex   +4 more sources

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. [PDF]

Circulation Research, 1994
The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this desensitization may in part be caused by an increase in beta-adrenergic receptor kinase (beta ARK) expression. beta ARK is thought to effect desensitization by acting in concert with an inhibitor protein, called beta-arrestin ...
Martin Ungerer, Giustino Parruti, Michael Böhm, Mechthild Puzicha, Antonio DeBlasi, Erland Erdmann, Martin J. Lohse   +6 more
openalex   +6 more sources

Association of the regulatory beta-adrenergic receptor kinase with rat liver microsomal membranes.

Journal of Biological Chemistry, 1994
beta-Adrenergic receptor kinase (beta ARK) is a regulatory enzyme involved in the modulation of beta-adrenergic and other G protein-coupled receptors. It has been described that beta ARK is a cytosolic protein that transiently translocates to the plasma membrane in order to specifically phosphorylate agonist-occupied receptors.
Irene García-Higuera, Petronila Penela, Cristina Murga, Gustavo Egea, Pedro Bonay, Jeffrey Benovic, Federico Mayor   +6 more
openalex   +4 more sources

Specific enhancement of beta-adrenergic receptor kinase activity by defined G-protein beta and gamma subunits. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1993
Sabine Müller, Mirko Hekman, Martin J. Lohse   +2 more
openalex   +2 more sources

Bovine Somatotropin Alters Myosin Heavy Chains and Beta Receptors in Skeletal Muscle of Feedlot Heifers with Little Impact on Live or Carcass Performance

Meat and Muscle Biology, 2021
The objective was to determine whether recombinant bovine somatotropin (rbST) enhanced live performance,skeletal muscle biological activity, and beta-adrenergic receptor expression of feedlot heifers during the finishing phase.
Alex Thompson, Bradley Johnson, Gary Vogel, Jerilyn Hergenreder, Jessica Baggerman, Kari Spivey, Rand Broadway, Tyler Harris, Zachary Smith   +8 more
doaj   +2 more sources

The Potential Anti-remodeling Effect of Paroxetine After Myocardial Infarction May Be Blunted by Beta-Blockers

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeft ventricular (LV) remodeling consists in maladaptive changes in cardiac geometry and function following an insult such as ST-segment elevation myocardial infarction (STEMI).
Oriol Iborra-Egea, Oriol Iborra-Egea, Alberto Aimo, Alberto Aimo, Nicola Martini, Carolina Galvez-Monton, Carolina Galvez-Monton, Silvia Burchielli, Giorgia Panichella, Claudio Passino, Claudio Passino, Michele Emdin, Michele Emdin, Antoni Bayes-Genis, Antoni Bayes-Genis, Antoni Bayes-Genis   +15 more
doaj   +1 more source

Rapid agonist‐induced beta‐adrenergic receptor kinase translocation in C6 glioma cells [PDF]

FEBS Letters, 1992
Exposure of C6 glioma cells to 1 μM isoproterenol leads to fast desensitization of the β‐adrenergic receptor/adenylyl cyclase system and transient receptor sequestration. It also triggers a very rapid and transient translocation to the plasma membrane or β‐adrenergic receptor kinase (βARK), a specific cytoplasmic kinase that phosphorylates only the ...
Irene García-Higuera, Federico Mayor
openalex   +5 more sources

Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase. [PDF]

Journal of Biological Chemistry, 1993
We have shown previously that GTP-binding regulatory protein (G protein) beta gamma subunits stimulate the agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors (mAChRs) and rhodopsin by a protein kinase partially purified from porcine brain (mAChR kinase) but not the phosphorylation of rhodopsin by rhodopsin kinase (Haga, K.
Kimihiko Kameyama, Kazuko Haga, Tatsuya Haga, Kenji Kontani, Toshiaki Katada, Yoshitaka Fukada   +5 more
openalex   +3 more sources