Results 21 to 30 of about 24,989 (236)

Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. [PDF]

PLoS ONE, 2014
Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors.
Jerry Curran, Lifei Tang, Steve R Roof, Sathya Velmurugan, Ashley Millard, Stephen Shonts, Honglan Wang, Demetrio Santiago, Usama Ahmad, Matthew Perryman, Donald M Bers, Peter J Mohler, Mark T Ziolo, Thomas R Shannon   +13 more
doaj   +1 more source

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

Journal of Biological Chemistry, 1993
Receptor-specific or homologous desensitization of beta 2-adrenergic receptors is thought to be effected via phosphorylation of the receptor by the beta-adrenergic receptor kinase (beta ARK), followed by binding of beta-arrestin. We have generated stably transfected Chinese hamster ovary cell lines overexpressing either of the two regulatory proteins ...
S, Pippig, S, Andexinger, K, Daniel, M, Puzicha, M G, Caron, R J, Lefkowitz, M J, Lohse   +6 more
openaire   +2 more sources

Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits

Antioxidants, 2021
Recent studies have shown that carbonyl stress is a causative factor of schizophrenia, categorized as carbonyl stress-related schizophrenia (CS-SCZ).
Shin Koike, Kazuya Toriumi, Sakura Kasahara, Yosuke Kibune, Yo-ichi Ishida, Takashi Dan, Toshio Miyata, Makoto Arai, Yuki Ogasawara   +8 more
doaj   +1 more source

Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation.

Journal of Biological Chemistry, 1993
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the activated form of multiple receptors such as the beta 2-adrenergic receptor (beta 2 AR) and rhodopsin. beta ARK also phosphorylates synthetic peptides, albeit with an approximately 10(4)-10(7)-fold lower Vmax/Km ratio as compared to receptors, with a clear preference for ...
C Y, Chen, S B, Dion, C M, Kim, J L, Benovic   +3 more
openaire   +2 more sources

Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. [PDF]

PLoS ONE, 2012
Glycyrrhetic acid (GA) exerts synergistic anti-asthmatic effects via a β₂-adrenergic receptor (β₂AR)-mediated pathway. Cholesterol is an important component of the structure and function of lipid rafts, which play critical roles in the β₂AR-Gs-adenylate ...
Qian Shi, Yuanyuan Hou, Jie Hou, Penwei Pan, Ze Liu, Min Jiang, Jie Gao, Gang Bai   +7 more
doaj   +1 more source

ROLE OF SUSTAINED SYMPATHETIC OVERACTIVATION IN THE DEVELOPMENT OF STRUCTURAL AND FUNCTIONAL MYOCARDIAL CHANGES IN HEART FAILURE

Кубанский научный медицинский вестник, 2018
Heart failure is associated with profound sympathetic overactivation, which initially develops as an adaptive effect that supports cardiac contractile function.
O. E. OSADCHII
doaj   +1 more source

Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling

Breast Cancer Research, 2022
Background Opioid and beta-adrenergic receptors are recently shown to cross talk via formation of receptor heterodimers to control the growth and proliferation of breast cancer cells.
Bénédicte Rousseau, Sengottuvelan Murugan, Ajay Palagani, Dipak K. Sarkar   +3 more
doaj   +1 more source

The octopamine receptor Octβ2R regulates ovulation in Drosophila melanogaster.

PLoS ONE, 2014
Oviposition is induced upon mating in most insects. Ovulation is a primary step in oviposition, representing an important target to control insect pests and vectors, but limited information is available on the underlying mechanism.
Junghwa Lim, Paul R Sabandal, Ana Fernandez, John Martin Sabandal, Hyun-Gwan Lee, Peter Evans, Kyung-An Han   +6 more
doaj   +1 more source

A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.

Journal of Biological Chemistry, 1994
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the activated form of the beta 2-adrenergic receptor (beta 2AR) and related G protein-coupled receptors. To further elucidate the role of beta ARK in receptor desensitization, we generated a beta ARK dominant negative mutant by converting an invariant lysine residue in the ...
G, Kong, R, Penn, J L, Benovic
openaire   +2 more sources

Rapid agonist‐induced beta‐adrenergic receptor kinase translocation in C6 glioma cells [PDF]

FEBS Letters, 1992
Exposure of C6 glioma cells to 1 μM isoproterenol leads to fast desensitization of the β‐adrenergic receptor/adenylyl cyclase system and transient receptor sequestration. It also triggers a very rapid and transient translocation to the plasma membrane or β‐adrenergic receptor kinase (βARK), a specific cytoplasmic kinase that phosphorylates only the ...
Garcia-Higuera, Irene, Mayor, Federico
openaire   +2 more sources