Results 21 to 30 of about 88,568 (304)

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. [PDF]

Proceedings of the National Academy of Sciences, 1989
Homologous (agonist-specific) desensitization of beta-adrenergic receptors (beta ARs) is accompanied by and appears to require phosphorylation of the receptors. We have recently described a novel protein kinase, beta AR kinase, which phosphorylates beta ARs in vitro in an agonist-dependent manner.
Lohse, MJ, Lefkowitz, RJ, Caron, MG, Benovic, JL   +3 more
openaire   +4 more sources

Essential role of β-adrenergic receptor kinase 1 in cardiac development and function [PDF]

Proceedings of the National Academy of Sciences, 1996
The β-adrenergic receptor kinase 1 (βARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. We have cloned and disrupted the βARK1 gene in mice by homologous recombination. No homozygote βARK1 −/−
Howard A. Rockman, Robert J. Lefkowitz, Mohamed Jaber, John Ross, Walter J. Koch, Bradley R. Smith, Marc G. Caron, Bruno Giros, Bruno Giros, Richard A. Bond, Kathleen K. Sulik   +10 more
openaire   +4 more sources

Association of the regulatory beta-adrenergic receptor kinase with rat liver microsomal membranes.

Journal of Biological Chemistry, 1994
beta-Adrenergic receptor kinase (beta ARK) is a regulatory enzyme involved in the modulation of beta-adrenergic and other G protein-coupled receptors. It has been described that beta ARK is a cytosolic protein that transiently translocates to the plasma membrane in order to specifically phosphorylate agonist-occupied receptors.
Irene García-Higuera, Petronila Penela, Cristina Murga, Gustavo Egea, Pedro Bonay, Jeffrey Benovic, Federico Mayor   +6 more
openalex   +4 more sources

Rapid agonist‐induced beta‐adrenergic receptor kinase translocation in C6 glioma cells [PDF]

FEBS Letters, 1992
Exposure of C6 glioma cells to 1 μM isoproterenol leads to fast desensitization of the β‐adrenergic receptor/adenylyl cyclase system and transient receptor sequestration. It also triggers a very rapid and transient translocation to the plasma membrane or β‐adrenergic receptor kinase (βARK), a specific cytoplasmic kinase that phosphorylates only the ...
Irene García-Higuera, Federico Mayor
openalex   +5 more sources

Structure of the human gene encoding the beta-adrenergic receptor kinase.

Journal of Biological Chemistry, 1994
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the agonist-occupied forms of the beta 2-adrenergic receptor and related G protein-coupled receptors. beta ARK is one of the best characterized members of a growing family of G protein-coupled receptor kinases.
Raymond B. Penn, Jeffrey Benovic
openalex   +4 more sources

Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation.

Journal of Biological Chemistry, 1993
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the activated form of multiple receptors such as the beta 2-adrenergic receptor (beta 2 AR) and rhodopsin. beta ARK also phosphorylates synthetic peptides, albeit with an approximately 10(4)-10(7)-fold lower Vmax/Km ratio as compared to receptors, with a clear preference for ...
Ching‐Yu Chen, Sarah Dion, C.M. Kim, Jeffrey Benovic   +3 more
openalex   +4 more sources

Unraveling the Mechanism of Impaired Osteogenic Differentiation in Osteoporosis: Insights from ADRB2 Gene Polymorphism [PDF]

Cells
Osteoporosis is characterized by increased resorption and decreased bone formation; it is predominantly influenced by genetic factors. G-protein coupled receptors (GPCRs) play a vital role in bone homeostasis, and mutations in these genes are associated ...
Olga Krasnova, Julia Sopova, Anastasiia Kovaleva, Polina Semenova, Anna Zhuk, Daria Smirnova, Daria Perepletchikova, Olga Bystrova, Marina Martynova, Vitaly Karelkin, Olga Lesnyak, Irina Neganova   +11 more
doaj   +2 more sources

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

Proceedings of the National Academy of Sciences of the United States of America, 1986
beta-Adrenergic receptor kinase (beta-AR kinase) is a cytosolic enzyme that phosphorylates the beta-adrenergic receptor only when it is occupied by an agonist [Benovic, J. Strasser, R. H., Caron, M. G. & Lefkowitz, R. J. (1986) Proc. Natl. Acad. Sci. USA
R. H. Strasser, Jeffrey Benovic, Marc G. Caron, Robert J. Lefkowitz   +3 more
openalex   +2 more sources

Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2. [PDF]

Journal of Clinical Investigation, 1995
Beta-adrenergic receptor kinase (beta ARK) is a serine-threonine kinase involved in the process of homologous desensitization of G-coupled receptors.
Antonio De Blasi, Giustino Parruti, Michele Sallese   +2 more
openalex   +2 more sources

Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1994
The roles of three protein kinases, cyclic AMP-dependent protein kinase (protein kinase A), protein kinase C, and beta-adrenergic receptor kinase (beta ARK), implicated in agonist-induced desensitization of guanine nucleotide-binding protein (G-protein ...
Meng-Fu Maxwell Shih, C C Malbon
openalex   +2 more sources