Results 31 to 40 of about 89,923 (320)
Frontiers in Physiology, 2021 Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes ...
Chul-Hong Park +5 more
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A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach
Biomolecules, 2021 Obesity is a low-grade systemic inflammatory disease involving adipocytokines. As though Anmyungambi decoction (AMGB) showed significant improvement on obesity in a clinical trial, the molecular mechanism of AMGB in obesity remains unknown. Therefore, we
Dongyeop Jang +3 more
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Involvement of the Catecholamine Pathway in Glioblastoma Development
Cells, 2021 Glioblastoma (GBM) is the most aggressive tumor of the central nervous system (CNS). The standard of care improves the overall survival of patients only by a few months. Explorations of new therapeutic targets related to molecular properties of the tumor
Zoltán Kraboth +5 more
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Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. [PDF]
PLoS ONE, 2012 The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation.
Fortune F Shea +4 more
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Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background ADRB1 (adrenergic receptor beta 1) responds to neuroendocrine stimulations, which have great implications in hypertension. GRK2 (G protein‐coupled receptor kinase 2) is an essential regulator for many G protein‐coupled receptors and subsequent
Xuejing Sun +9 more
doaj +1 more source
Breast Cancer: Basic and Clinical Research, 2008 Previous data from our laboratory have indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in breast cancer cell lines and that these pathways ...
Michael W. Hance +2 more
doaj +2 more sources
The β-Adrenergic Receptor Kinase (GRK2) Is Regulated by Phospholipids [PDF]
Journal of Biological Chemistry, 1995 The beta-adrenergic receptor kinase (beta ARK) is a member of growing family of G protein coupled receptor kinases (GRKs). beta ARK and other members of the GRK family play a role in the mechanism of agonist-specific desensitization by virtue of their ability to phosphorylate G protein-coupled receptors in an agonist-dependent manner.
Yu Liu +4 more
openaire +3 more sources
Frontiers in Physiology, 2021 We previously showed that the beta-3 adrenergic receptor (BAR3) is expressed in most segments of the nephron where its agonism promotes a potent antidiuretic effect.
Serena Milano +8 more
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Proceedings of the National Academy of Sciences of the United States of America, 1994 James Inglese +5 more
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The β-Adrenergic Receptor Is a Substrate for the Insulin Receptor Tyrosine Kinase [PDF]
Journal of Biological Chemistry, 1996 G-protein-linked receptors and intrinsic tyrosine-kinase growth receptors represent two prominent modalities in cell signaling. Cross-regulation among members of both receptor superfamilies has been reported, including the counter-regulatory effects of insulin on beta-adrenergic catecholamine action.
Baltensperger, Kurt +5 more
openaire +4 more sources