Results 31 to 40 of about 24,989 (236)

Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C [PDF]

Journal of Biological Chemistry, 1995
The aim of this study was to test the possible modification of beta-adrenergic receptor kinase (beta ARK) activity by second messengers and/or their downstream components. Using human mononuclear leukocytes (MNL), we found that calcium ionophores could elevate beta ARK activity by about 80% in a protein kinase C (PKC)-dependent manner.
Chuang TT, LeVine H. 3rd, DE BLASI, ANTONIO   +2 more
openaire   +4 more sources

Stevioside modulates oxidative damage in the liver and kidney of high fat/low streptozocin diabetic rats

Heliyon, 2018
This study investigated the potential of stevioside to prevent oxidative DNA damage in the liver and kidney of type 2 diabetes mellitus (T2DM) using high fat-low streptozocin rat model. Rats were treated daily with 12.5, 25 and 50 mg/kg stevioside orally
Solomon Oladapo Rotimi, Oluwakemi Anuoluwapo Rotimi, Isaacson Bababode Adelani, Chinonye Onuzulu, Patience Obi, Rotimi Okungbaye   +5 more
doaj   +1 more source

Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]

Research Results in Pharmacology, 2022
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Oke, Blessing Ejimadu, Isaiah Olaoye, Oluwabukola Oyegbenro, Taiwo Salami, Romilola Basorun, Oluwafisayomi Oluwadare, Yetunde Salawudeen   +10 more
doaj   +3 more sources

Mechanism of beta-adrenergic receptor kinase activation by G proteins

Journal of Biological Chemistry, 1993
The beta-adrenergic receptor kinase (beta-ARK) specifically phosphorylates the activated form of various G protein-coupled receptors such as the beta 2-adrenergic receptor (beta 2-AR). Recently, G protein beta gamma subunits have been demonstrated to activate beta-ARK-mediated receptor phosphorylation.
C M, Kim, S B, Dion, J L, Benovic
openaire   +2 more sources

Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes

Molecular Metabolism, 2018
Objective: The inappropriate release of free fatty acids from obese adipose tissue stores has detrimental effects on metabolism, but key molecular mechanisms controlling FFA release from adipocytes remain undefined.
Shangyu Hong, Wei Song, Peter-James H. Zushin, Bingyang Liu, Mark P. Jedrychowski, Amir I. Mina, Zhaoming Deng, Dimitrije Cabarkapa, Jessica A. Hall, Colin J. Palmer, Hassan Aliakbarian, John Szpyt, Steven P. Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S. Banks   +16 more
doaj   +1 more source

EH Domain-Containing 2 Deficiency Restricts Adipose Tissue Expansion and Impairs Lipolysis in Primary Inguinal Adipocytes

Frontiers in Physiology, 2021
Lipid uptake can be facilitated via caveolae, specific plasma membrane invaginations abundantly expressed in adipocytes. The dynamin-related protein EH domain-containing 2 (EHD2) stabilizes caveolae at the cell surface.
Claes Fryklund, Björn Morén, Shrenika Shah, Mario Grossi, Eva Degerman, Claudia Matthaeus, Karin G. Stenkula   +6 more
doaj   +1 more source

Opposing Actions of Adrenocorticotropic Hormone and Glucocorticoids on UCP1-Mediated Respiration in Brown Adipocytes

Frontiers in Physiology, 2019
Brown fat is a potential target in the treatment of metabolic disorders as recruitment and activation of this thermogenic organ increases energy expenditure and promotes satiation.
Katharina Schnabl, Katharina Schnabl, Katharina Schnabl, Julia Westermeier, Julia Westermeier, Yongguo Li, Yongguo Li, Martin Klingenspor, Martin Klingenspor, Martin Klingenspor   +9 more
doaj   +1 more source

The β-Adrenergic Receptor Kinase (GRK2) Is Regulated by Phospholipids [PDF]

Journal of Biological Chemistry, 1995
The beta-adrenergic receptor kinase (beta ARK) is a member of growing family of G protein coupled receptor kinases (GRKs). beta ARK and other members of the GRK family play a role in the mechanism of agonist-specific desensitization by virtue of their ability to phosphorylate G protein-coupled receptors in an agonist-dependent manner.
J J, Onorato, M E, Gillis, Y, Liu, J L, Benovic, A E, Ruoho   +4 more
openaire   +2 more sources

Counter effects of Asiaticosids-D through putative neurotransmission on rotenone induced cerebral ganglionic injury in Lumbricus terrestris

IBRO Reports, 2019
Asiaticoside-D (AD) was shown to efficacy of ganglionic degenerated Lumbricus terrestris as a pioneering observation in our earlier research. Though, extract molecular mechanisms of AD for degenerative diseases (DDs) remains largely unknown.
Mamangam Subaraja, Arambakkam Janardhanam Vanisree   +1 more
doaj   +1 more source

Inhibition of the beta-adrenergic receptor kinase by polyanions.

The Journal of biological chemistry, 1989
The beta-adrenergic receptor kinase, which specifically phosphorylates the agonist-occupied beta-adrenergic receptor, is strongly inhibited by polyanions. Heparin and dextran sulfate inhibit the enzyme with an IC50 of approximately 0.15 microM. De-N-sulfated heparin is approximately 8-fold less potent.
J L, Benovic, W C, Stone, M G, Caron, R J, Lefkowitz   +3 more
openaire   +2 more sources