Results 61 to 70 of about 24,989 (236)
COVID‐19 and renin angiotensin aldosterone system: Pathogenesis and therapy
Health Science Reports, 2021 Aims The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) binds to the ACE2 component of the renin‐angiotensin aldosterone system (RAAS) and infects the human cells.
Fatemeh Babajani +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Background: As an effective antitumor drug, doxorubicin (DOX) is primarily used to treat solid tumors and hematologic malignancies. However, increasing evidence has emerged indicating its cardiotoxicity, and few solutions have been proposed to counter ...
Cuiliu Jin +6 more
doaj +1 more source
Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial
ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad +9 more
wiley +1 more source
Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptor
Communications BiologyThe receptor tyrosine kinase EphA2 drives cancer malignancy by facilitating metastasis. EphA2 can be found in different self-assembly states: as a monomer, dimer, and oligomer.
Ryan J. Schuck +11 more
doaj +1 more source
Frontiers in Physiology, 2017 Chronic stress induces endocrine disturbance, which contributes to the development of polycystic ovary syndrome (PCOS), a condition that remains a challenge for clinicians to cope with.
Hao-Yu Sun +28 more
doaj +1 more source
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
The Effect of Atenolol on CK-MB Levels in Hypertensive Patients
Iraqi Journal of Pharmaceutical Sciences, 2017 Atenolol is one of beta-adrenergic receptor blocking agent. It is widely used for the treatment of hypertension as a selective antihypertensive drug. But long term usage of atenolol may cause one of the cardiovascular diseases like myocardial infarction.
Inaam A. Amin
doaj +3 more sources
Characterization and inhibition of β-adrenergic receptor kinase in intact myocytes [PDF]
Cardiovascular Research, 1997 beta-Adrenergic receptor kinase (beta ARK) phosphorylates and thereby inactivates agonist-occupied beta-adrenergic receptors (beta AR). beta ARK is thought to play an important role in the regulation of cardiac function. Therefore, we studied beta ARK activation and its inhibition in intact smooth muscle cells and in cardiomyoblasts.beta AR agonist ...
K L, Laugwitz +6 more
openaire +2 more sources
Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.
PLoS ONE, 2010 With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Sarah Auburn +14 more
doaj +1 more source
Physiological Reports, 2022 Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1).
Kyle D. Medak +4 more
doaj +1 more source