Results 71 to 80 of about 57,900 (247)

Ginsenoside Rb1 Induces Beta 3 Adrenergic Receptor–Dependent Lipolysis and Thermogenesis in 3T3-L1 Adipocytes and db/db Mice

Frontiers in Pharmacology, 2019
Obesity is constantly rising into a major health threat worldwide. Activation of brown-like transdifferentiation of white adipocytes (browning) has been proposed as a promising molecular target for obesity treatment.
Seona Lim, Seona Lim, Jinbong Park, Jinbong Park, Jae-Young Um, Jae-Young Um, Jae-Young Um   +6 more
doaj   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Cardioimmunologic response patterns after an acute heart failure event: Design and first results of AHF‐ImmunoCS

ESC Heart Failure, EarlyView.
Abstract Aims We have previously shown that patients who develop heart‐reactive antibodies (HRAs) de novo after a heart failure (HF) hospitalization are at increased risk of adverse outcomes, lending weight to the hypothesis that B cells may play a pivotal role in HF progression.
Niklas Beyersdorf, Boshra Afshar, Dora Pelin, Maximilian Bauser, Elisa Kaiser, Janna Lamers, Jannika Pätkau, Mairin Heil, Dennis Göpfert, Hanna Hepp, Wafaa Al Hassan, Thomas Kerkau, Fabian Kerwagen, Roland Jahns, Valerie Boivin‐Jahns, Stefan Frantz, Gustavo Ramos, Ulrich Hofmann, Stefan Störk, Caroline Morbach   +19 more
wiley   +1 more source

Transcriptomic and proteomic profiling shows dysregulated immune and metabolic pathways in arrhythmogenic cardiomyopathy

ESC Heart Failure, EarlyView.
Abstract Aims Arrhythmogenic cardiomyopathy (ACM) is a hereditary heart disease characterized by fibrofatty myocardial replacement and a predisposition to malignant ventricular arrhythmias. The underlying pathomechanisms remain incompletely understood, and specific disease markers are sparse.
Deniz Akdis, Lukas Weidmann, Paolo Nanni, Anna Gaertner, Hendrik Milting, Peter Bode, Corinna Brunckhorst, Liang Chen, Felix C. Tanner, Frank Ruschitzka, Ardan M. Saguner, Firat Duru   +11 more
wiley   +1 more source

The β3 Adrenergic Receptor Agonist CL316243 Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats by Activating AMPK/PGC-1α Signaling in Skeletal Muscle

Diabetes, Metabolic Syndrome and Obesity, 2021
Li-Na Ding,1,* Ya Cheng,1,* Lu-Yao Xu,1 Le-Quan Zhou,1,2 Li Guan,1,2 Hai-Mei Liu,1,2 Ya-Xing Zhang,1,2 Run-Mei Li,1 Jin-Wen Xu1,2 1The Research Center of Basic Integrative Medicine, Basic Medical College, Guangzhou University of Chinese Medicine ...
Ding LN, Cheng Y, Xu LY, Zhou LQ, Guan L, Liu HM, Zhang YX, Li RM, Xu JW   +8 more
doaj  

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Mechanisms of Action Involved in the In Vivo Gastroprotective Response of Fruits: A Systematic Review

Food Frontiers, EarlyView.
ABSTRACT Gastrointestinal diseases remain a significant global health concern, primarily due to the limitations of current pharmacological treatments, which often come with adverse side effects and high recurrence rates. This situation highlights the urgent need for safer and more effective alternatives.
Isabel Sousa Alcântara, Renata Torres Pessoa, Lucas Yure Santos da Silva, Tarcisio Mendes Silva, Isis Oliveira Menezes, Anita Oliveira Brito Pereira Bezerra Martins, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley   +7 more
wiley   +1 more source

Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.

Circulation Research, 1999
Cardiac beta(2)-adrenergic receptor (beta(2)AR) overexpression is a potential contractile therapy for heart failure. Cardiac contractility was elevated in mice overexpressing beta(2)ARs (TG4s) with no adverse effects under normal conditions.
H. R. Cross, C. Steenbergen, R. Lefkowitz, W. Koch, E. Murphy   +4 more
semanticscholar   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source

Overexpression of a Neuronal Type Adenylyl Cyclase (Type 8) in Sinoatrial Node Markedly Impacts Heart Rate and Rhythm

Frontiers in Neuroscience, 2019
Heart rate (HR) and HR variability (HRV), predictors of over-all organism health, are widely believed to be driven by autonomic input to the sinoatrial node (SAN), with sympathetic input increasing HR and reducing HRV. However, variability in spontaneous
Jack M. Moen, Jack M. Moen, Michael G. Matt, Michael G. Matt, Christopher Ramirez, Kirill V. Tarasov, Khalid Chakir, Yelena S. Tarasova, Yevgeniya Lukyanenko, Kenta Tsutsui, Oliver Monfredi, Oliver Monfredi, Christopher H. Morrell, Christopher H. Morrell, Syevda Tagirova, Yael Yaniv, Thanh Huynh, Karel Pacak, Ismayil Ahmet, Edward G. Lakatta   +19 more
doaj   +1 more source