Results 91 to 100 of about 104,267 (299)

Beta-Blocker Type Effect on Substrate Oxidation during HIIE in Heart Failure Patients: Pilot Data

Arquivos Brasileiros de Cardiologia
The effect of third and second-generation type of beta-blocker on substrate oxidation especially during high-intensity exercises are scarce. The objective of the study is to explore differences of beta-blocker regimens (vasodilating vs.
Paula Aver Bretanha Ribeiro, Eve Normandin, Philippe Meyer, Martin Juneau, Michel White, Anil Nigam, Mathieu Gayda   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of β-blocker selectivity on long-term outcomes in congestive heart failure patients with chronic obstructive pulmonary disease

, 2015
Yoshiaki Kubota, Kuniya Asai, Erito Furuse, Shunichi Nakamura, Koji Murai, Yayoi Tetsuou Tsukada, Wataru Shimizu Department of Medicine (Division of Cardiology), Nippon Medical School, Bunkyo-ku, Tokyo, Japan Background: Chronic obstructive ...
Kubota Y, Furuse E, Murai K, Asai K, Shimizu W, Nakamura S, Tsukada YT   +6 more
core  

Beta-blocker therapy after acute myocardial infarction with preserved ejection fraction : observational and clinical studies

BackgroundCardiovascular disease, with its feared primary presentation of acute myocardial infarction (AMI), remains the leading cause of morbidity and mortality globally.
Katarina Mars (18661267)
core   +1 more source

Prior beta blocker treatment decreases leukocyte responsiveness to injury

, 2019
Following injury, leukocytes are released from hematopoietic organs and migrate to the site of damage to regulate tissue inflammation and repair; however, leukocytes lacking beta(2)-adrenergic receptor (beta(2)-AR) expression have marked impairments in ...
Grisanti L. A., De Lucia C., Gao E., Stark A., Sardu C., Strony J. T., Tilley D. G., Koch W. J., Myers V. D., Thomas T. P., Yu D., Marfella R., Beretta R., Hamad E. A., Houser S. R.   +14 more
core   +1 more source

Changes in body composition in patients with left ventricular systolic dysfunction initiated on beta-blocker therapy [PDF]

, 2007
Background: Increasing body mass index, cholesterol and body fat are associated with a better prognosis in patients with left ventricular systolic dysfunction (LVSD).
Cleland, John G.J.F., Ingle, Lee, Carroll, Sean, Cleland, John, Cooke, Carlton B., Clark, Andrew L., Butterly, Ron, King, Rod F., Rigby, Alan S.   +8 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Increase of 1-year Mortality After Perioperative Beta-blocker Withdrawal in Endovascular and Vascular Surgery Patients

, 2007
ObjectivesTo assess the relation between beta-blocker use, underlying cardiac risk, and 1-year outcome in vascular surgery patients, including the effect of beta-blocker withdrawal.DesignProspective survey.Materials711 consecutive peripheral vascular ...
Simoons, Maarten, Boersma, E., Scholte op Reimer, WJM (Wilma), Bax, J.J., Poldermans, D, Hoeks, Sanne; id_orcid, Hoeks, S.E., Poldermans, D., van Urk, H., Simoons, M.L., van Urk, H, Boersma, Eric, Hoeks, Sanne, Scholte op Reimer, W.J.M., Bax, JJ, Jörning, P.J.G., Jorning, PJG   +16 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Outpatient adherence to beta-blocker therapy after acute myocardial infarction

, 2002
ObjectivesThis study was designed to determine adherence to outpatient beta-blocker therapy following acute myocardial infarction (AMI).BackgroundThe importance of beta-blocker therapy after AMI is widely recognized.
Javed Butler, Rhonda BeLue, Ray, Wayne A, Daugherty, James, James Daugherty, Manoj K Jain, Wayne A Ray, Jain, Manoj K, Patrick G Arbogast, Arbogast, Patrick G, Griffin, Marie R, BeLue, Rhonda, Butler, Javed, Marie R Griffin   +13 more
core   +1 more source