Results 161 to 170 of about 189,690 (343)

Certain beta-blockers can decrease beta-adrenergic receptor number: II. Down-regulation of receptor number by alprenolol and propranolol in cultured lymphoma and muscle cells. [PDF]

, 1988
Richard J. Hughes, L C Mahan, Paul A. Insel   +2 more
openalex   +1 more source

Long-term effects of beta-blocker use on lung function in Japanese patients with chronic obstructive pulmonary disease

International Journal of COPD, 2017
Naohiro Oda,1 Nobuaki Miyahara,1,2 Hirohisa Ichikawa,3 Yasushi Tanimoto,4 Kazuhiro Kajimoto,5 Makoto Sakugawa,6 Haruyuki Kawai,7 Akihiko Taniguchi,1 Daisuke Morichika,1 Mitsune Tanimoto,1 Arihiko Kanehiro,1 Katsuyuki Kiura1 1Department of Allergy and ...
Oda N, Miyahara N, Ichikawa H, Tanimoto Y, Kajimoto K, Sakugawa M, Kawai H, Taniguchi A, Morichika D, Tanimoto M, Kanehiro A, Kiura K   +11 more
doaj  

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Kinetic Analysis of Therapeutic Doses of &beta;-Blockers for Angina Pectoris Based on Receptor Occupancy Theory : Relationship between &beta;<SUB>1</SUB>-Receptor Occupancy or Vasodilative Action and Dose

, 1999
Yasuhiko Yamada, Kyoko Matsuyama, Risa Takayanagi, Hajime Kotaki, Yasufumi Sawada, Tatsuji Iga   +5 more
openalex   +2 more sources

Observation on the efficacy and pharmacokinetics of betaxolol (SL 75212), a cardioselective beta‐adrenoceptor blocking drug. [PDF]

, 1981
K Balnave, JD Neill, CJ Russell, DW Harron, WJ Leahey, Richard Wilson, RG Shanks   +6 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Adrenergic &beta;-Receptor Blocking Activity of (3-Amino-2-hydroxy) propoxy-3, 4-dihydrocarbestyril Derivatives in Anesthetized Dog

, 1974
KAZUYUKI NAKAGAWA, NANAMI MORAKAMI, S. YOSHIZAKI, Michiaki Tominaga, Hideo Mori, Youichi Yabuuchi, SHIGEYURI SHINTANI   +6 more
openalex   +2 more sources

Can insulin-treated diabetics be given beta-adrenergic blocking drugs? [PDF]

, 1980
A H Barnett, Daniel B. Leslie, Peter Watkins   +2 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Angiotensin II receptor antagonists for the treatment of heart failure: what is their place after ELITE-II and Val-HeFT? [PDF]

, 2001
McMurray, John J.V.
core   +1 more source