Results 61 to 70 of about 189,690 (343)

The use of beta-blockers before major trauma and posttrauma outcome: A nationwide population-based study

Journal of Medical Sciences, 2022
Background: Beta-blockers are widely used for the treatment of arrhythmia, hypertension, and congestive heart failure. Major trauma causes significant blood loss and subsequent tachycardia and hypotension.
Jen-Chun Wang, Wu-Chien Chien, Chi-Hsiang Chung, Po-Chuan Chen, Chin-Li Chen, Shih-Hung Tsai   +5 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Resting heart rate in ambulatory heart failure with reduced ejection fraction treated with beta‐blockers

ESC Heart Failure, 2020
Aims Current guidelines recommend beta‐blocker therapy in chronic heart failure with reduced ejection fraction (HFrEF) titrated according to tolerated target dose. The efficiency of this strategy to obtain adequate heart rate (HR) control remains unclear
Kenneth D. Varian, Xinge Ji, Justin L. Grodin, Frederik H. Verbrugge, Alex Milinovich, Michael W. Kattan, W.H. Wilson Tang   +6 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model [PDF]

, 2012
Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents.
Itano, Yoshitaro, Kaku, Ryuji, Kanzaki, Hirotaka, Matsuoka, Yoshikazu, Mizobuchi, Satoshi, Morita, Kiyoshi, Nishie, Hiroyuki, Obata, Norihiko, Ouchida, Mamoru, Taniguchi, Arata, Tomotsuka, Naoto   +10 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Effectiveness of preJhospital betaJblocker therapy in patients with acute coronary syndrome

Российский кардиологический журнал, 2008
To assess the effectiveness of pre-hospital beta-blocker therapy in patients with acute coronary syndrome (ACS), 76 individuals with Q-wave myocardial infarction (Q-MI), and 62 persons with non-Q wave MI (non-Q-MI) were examined.
G. M. Baitova, Y. M. Madyarova, M. T. Beyshenkulov   +2 more
doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Beta-Blocker Use in Pregnancy and Risk of Specific Congenital Anomalies: A European Case-Malformed Control Study. [PDF]

, 2017
The prevalence of chronic hypertension is increasing in pregnant women. Beta-blockers are among the most prevalent anti-hypertensive agents used in early pregnancy.
Addor, M.C., Bakker, M.K., Barisic, I., Bergman, JEH, Cavero-Carbonell, C., Dolk, H., Gans, ROB, Garne, E., Gatt, M., Klungsoyr, K., Lelong, N., Loane, M., Lutke, L.R., Lynch, C., Mokoroa, O., Nelen, V., Neville, A.J., Pierini, A., Randrianaivo, H., Rissmann, A., Tucker, D., Wiesel, A.   +21 more
core   +4 more sources

Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure

Patient Preference and Adherence, 2016
Catherine Girouard,1–3 Jean-Pierre Grégoire,1–3 Paul Poirier,2,4 Jocelyne Moisan1–3 1Chair on Adherence to Treatments, Université Laval, 2Faculty of Pharmacy, Université Laval, 3Population Health and Optimal Health
Girouard C, Grégoire JP, Poirier P, Moisan J   +3 more
doaj