Results 141 to 150 of about 865,952 (246)

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

AGRN activates GPX4 via the Wnt/beta-catenin signaling pathway to suppress ferroptosis in cervical cancer cells. [PDF]

Brief Funct Genomics
Fu A, Cai J, Chen R, Zou X, Chen Y, Fu F, Zhang W, Huang L, Ye Y, Li R, Mai B.   +10 more
europepmc   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Dual repression modes triggered by constitutively stabilized beta-catenin in the dorsal neural tube underlie cell fate alterations of the roof plate, neural crest, and dorsal interneurons. [PDF]

Cell Biosci
Saha SK, Zhao T, Reynolds K, McMahon M, Zhou CJ.   +4 more
europepmc   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish

, 2010
Caveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively regulates a number of cellular signaling events including canonical Wnt signaling Activation of the Wnt/beta-catenin pathway is essential for dorsal organizer ...
Li, Qing, Li, Yuanyuan, Mo, Saijun, Wang, Lu, Li, Jie, Cui, ZB, Chinese Acad Sci, Inst Hydrobiol, 7 S Donghu Rd, Wuhan 430072, Hubei, Peoples R China, Cui, Zongbin, Thannickal, Victor J.   +7 more
core  

E-Cadherin and Beta-Catenin Immunoexpression In Endometrioid Endometrial Carcinoma

Global Journal of Medicine and Public Health
Background Endometrial carcinoma is the most common invasive cancer of female genital tract. It is classified into type 1 and type 2, of which endometrioid carcinoma belongs to type 1 endometrial carcinoma and accounts for 85% of cases ...
Anu T R, Rahul Rajeev, Lovely Jose, Krishna Raj J S, Seeja Sumedhan   +4 more
doaj  

Differential expression of c-kit, E-cadherin, and beta-catenin in endometriosis and normal endometrial tissue. [PDF]

Turk J Obstet Gynecol
Ayhan Atasayar E, Şendağ F, Serin G, Akdemir A.   +3 more
europepmc   +1 more source

Immunohistochemical expression of beta-catenin in ampullary adenocarcinoma: a cross-sectional retrospective study. [PDF]

Ann Med Surg (Lond), 2023
Mirza SA, Hilmi MN, Al Jaleeli AN.
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source