Results 171 to 180 of about 163,662 (341)

Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure.

, 1994
R Yano, Melanie Oakes, Michelle M. Tabb, M Nomura   +3 more
openalex   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

<p>Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3&beta;/&beta;-catenin signal pathway</p>

, 2019
Deng Zang, Chao Niu, Haji Akber Aisa
openalex   +2 more sources

Beta-catenin

Beta-catenin (CTNNB1) plays a dual role in the cell, functioning both in cell adhesion and WNT signalling. In cell adhesion, CTNNB1 binds to cadherins in adherens junctions and anchors them to the cytoskeleton. This is crucial for reinforcing cell-cell junctions and maintaining structural integrity.
openaire   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Nuclear translocation of beta catenin in patients with Rathke cleft cysts-clinical and imaging characteristics and risk of recurrence. [PDF]

Acta Neurochir (Wien), 2023
Schmutzer M, Thorsteinsdottir J, Weller J, Rachinger W, Schichor C, Thon N, Ueberschaer M.   +6 more
europepmc   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

The VAX2-SERPINE1 axis modulates colorectal cancer cell proliferation and apoptosis through WNT/beta-catenin signaling. [PDF]

Transl Oncol
Zhang J, Liu G, Peng S, Chen Y, Xie Y, Lei Y, Wu J, Huang X, Wei X, Hong L, Yang P, Peng Y, Tang W, Wu X, Li A, Liu S, Shi X, Xiong J, Wang J.   +18 more
europepmc   +1 more source

Immunohistochemical expression of beta-catenin in ampullary adenocarcinoma: a cross-sectional retrospective study. [PDF]

Ann Med Surg (Lond), 2023
Mirza SA, Hilmi MN, Al Jaleeli AN.
europepmc   +1 more source

Dickkopf-1 enhances migration of HEK293 cell by beta-catenin/E-cadherin degradation [PDF]

, 2009
Haibin Kuang
openalex   +1 more source