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Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors
Cancer Treatment Reviews, 2018Nithya Krishnamurthy, Razelle Kurzrock
exaly
2007
Beta-catenin is a 92-kDa protein first identified as a molecule associated with the cytoplasmic tail of E-cadherin, as it links E-cadherin to the cytoskeleton. It is a key element in the WNT pathway. In the cytoplasm, beta-catenin forms a complex together with adenomatous polyposis coli (APC) tumor suppressor protein, axin and GSK3beta.
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Beta-catenin is a 92-kDa protein first identified as a molecule associated with the cytoplasmic tail of E-cadherin, as it links E-cadherin to the cytoskeleton. It is a key element in the WNT pathway. In the cytoplasm, beta-catenin forms a complex together with adenomatous polyposis coli (APC) tumor suppressor protein, axin and GSK3beta.
openaire +1 more source

