Results 41 to 50 of about 276,730 (267)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The Connection between Systematic Risk and Corporate Income Tax (A case study of the Tehran Stock Exchange) [PDF]

open access: yesFaslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2014
Corporate income taxes are the major source of tax revenues. This tax affects the systematic risks that companies confront with. Based on the data about 283 companies over period 2004-2011, we use random effects panel data models to examine the ...
Ayub Abozari   +2 more
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

The dynamics of the beta coefficient of stock prediction in the framework of structural macroeconomic models [PDF]

open access: yesتصمیم گیری و تحقیق در عملیات, 2019
The present research is aimed at predicting the beta coefficient (systematic risk) prediction dynamics within the framework of two macroeconomic structural models, the model in the context of dynamic stochastic general equilibrium (DSGE) and Panel Vector
Meisam Kaviani
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Assessing the dynamics of the average capital cost of the largest Russian companies after 2022

open access: yesВестник университета
The dynamics of the WACC indicator of Russian real sector companies has been assessed. The purpose of the study is to assess the dynamics of the capital cost of Russian companies and how it will affect their decisions.
S. V. Korzhnev
doaj   +1 more source

Assessment of the performance of haematological and non-invasive fibrotic indices for the monitoring of chronic HBV infection: a pilot study in a Ghanaian population

open access: yesBMC Research Notes, 2023
Objective Haematological and liver fibrotic markers could be appreciably utilized for effective monitoring of Chronic Hepatitis B viral (HBV) infection, thereby increasing patient’s treatment outcome.
Eric N. Y. Nyarko   +4 more
doaj   +1 more source

Research of investment risk using beta coefficient [PDF]

open access: yesInterdisciplinary Management Research, 2014
Beta coefcient is a measure of the investment or asset’s systematic risk in relation to the overall stock market. It enables comparison of a level of the risk of investments or assets with di€ferent characteristics. Before interpretation of its results, it is necessary to understand the speci city of this coeficient, the conditions of the capital ...
Domagoj Karacic, Ivana Bestvina Bukvic
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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