Results 51 to 60 of about 275,407 (267)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The Connection between Systematic Risk and Corporate Income Tax (A case study of the Tehran Stock Exchange) [PDF]
Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2014 Corporate income taxes are the major source of tax revenues. This tax affects the systematic risks that companies confront with. Based on the data about 283 companies over period 2004-2011, we use random effects panel data models to examine the ...
Ayub Abozari +2 more
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BMC Research Notes, 2023 Objective Haematological and liver fibrotic markers could be appreciably utilized for effective monitoring of Chronic Hepatitis B viral (HBV) infection, thereby increasing patient’s treatment outcome.
Eric N. Y. Nyarko +4 more
doaj +1 more source
Research of investment risk using beta coefficient [PDF]
Interdisciplinary Management Research, 2014 Beta coefcient is a measure of the investment or asset’s systematic risk in relation to the overall stock market. It enables comparison of a level of the risk of investments or assets with diferent characteristics. Before interpretation of its results, it is necessary to understand the speci city of this coeficient, the conditions of the capital ...
Domagoj Karacic, Ivana Bestvina Bukvic
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Assessing the dynamics of the average capital cost of the largest Russian companies after 2022
Вестник университетаThe dynamics of the WACC indicator of Russian real sector companies has been assessed. The purpose of the study is to assess the dynamics of the capital cost of Russian companies and how it will affect their decisions.
S. V. Korzhnev
doaj +1 more source