Results 61 to 70 of about 2,219,834 (339)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

NATIONAL AND REGIONAL COORDINATES OF THE REAL CONVERGENCE PROCESS INTENSITY IN THE ENLARGED EUROPEAN UNION [PDF]

CES Working Papers, 2012
Real convergence of EU economies can be approached from the perspective of close relations between the state of homogeneity and the existence of conditions that can facilitate it. In this paper we test the hypothesis of beta convergence at national level
Iulia Andreea Bucur
doaj  

Convergence processes of selected demographic indicators in regions of the Czech Republic

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2010
A number of authors deal with problems of convergence, divergence and disparities, particularly with reference to economic growth and its comparison in groups of countries.
Bohumil Minařík, Jaroslav Dufek, Zlata Sojková   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

In Search of Income Convergence and Ideal Distribution – the Case of European Union Regions

Comparative Economic Research
In the field of economics and regional research, income convergence between countries and regions has been analysed since the 1980s. At the beginning of the 21st century, a number of articles addressing income convergence of European Union (EU) countries
Beata Bal‑Domańska
doaj   +1 more source

On entire Dirichlet series similar to Hadamard compositions

Математичні Студії, 2023
A function $F(s)=\sum_{n=1}^{\infty}a_n\exp\{s\lambda_n\}$ with $0\le\lambda_n\uparrow+\infty$ is called the Hadamard composition of the genus $m\ge 1$ of functions $F_j(s)=\sum_{n=1}^{\infty}a_{n,j}\exp\{s\lambda_n\}$ if $a_n=P(a_{n,1},...,a_{n,p ...
O.M. Mulyava, M. M. Sheremeta
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Lack of Global Convergence and the Formation of Multiple Welfare Clubs across Countries: An Unsupervised Machine Learning Approach

Economies, 2019
The cross-country convergence hypothesis is one of the central topics of long-run macroeconomics. This paper revisits this hypothesis in a context beyond GDP.
Carlos Mendez
doaj   +1 more source

Mind the Gap: The Efficiency Convergence of ASEAN Plus Three Economies

JDE (Journal of Developing Economies), 2023
This study aims to examine the performance of technical efficiency convergence (Beta and Sigma convergences) of 10 ASEAN economies as well as other three main partners from East Asia, namely China, South Korea, and Japan for the years of 1990-2021, and ...
Mohammad Zeqi Yasin
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source