Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
About regional convergence clubs in the European Union [PDF]
The goal of this research is to present the concept of convergence club within the European Union members, starting from the hypothesis that an overall convergence cannot be identified because of the high output disparities between ...
Mihaela Simionescu
doaj
Is competitiveness in the European Union converging?
The convergence process has for many decades captured the attention of economists and its importance has especially increased with deepening economic integration.
Pavlína Balcarová
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Sigma Convergence versus Beta Convergence: Evidence from U.S. County-Level Data [PDF]
In this paper we outline (i) why sigma-convergence may not accompany beta-convergence, (ii) discuss evidence of beta-convergence in the U.S., and (iii) use U.S.
Levy, Daniel +2 more
core +2 more sources
Economic convergence of the Western Balkans towards the EU-15
This paper aims to analyze the beta convergence of Western Balkan countries towards the EU-15 Member States in the period 2004-2016, and two sub-periods: 2004-2008 and 2009-2013.
Sándor Gyula Nagy, Dzenita Siljak
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
In Search of Income Convergence and Ideal Distribution – the Case of European Union Regions
In the field of economics and regional research, income convergence between countries and regions has been analysed since the 1980s. At the beginning of the 21st century, a number of articles addressing income convergence of European Union (EU) countries
Beata Bal‑Domańska
doaj +1 more source
European and global financial integration: some panel evidence of the convergence of interest rates [PDF]
This paper seeks to contribute to the literature on financial integration using panel estimates to test beta- and sigma-convergence across the European Union countries’ interest rates and towards two specific benchmarks — the German and US rates ...
Cândida Ferreira
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source

