Results 101 to 110 of about 1,706,661 (335)

The Beta Transmuted Weibull Distribution

open access: yesAustrian Journal of Statistics, 2014
The paper introduces a beta transmuted Weibull distribution, which contains a number of distributions as special cases. The properties of the distribution are discussed and explicit expressions are derived for the mean deviations, Bonferroni and Lorenz ...
Manisha Pal, Montip Tiensuwan
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

A Novel Alternative to the Beta and Kumaraswamy Distributions for Double Bounded Hydroclimatology Data

open access: yesIEEE Access
The beta distribution is considered the most popular for modeling double-bounded data, such as rates and percentages. But when it comes to double-bounded hydrological data, it often does not show an adequate fit to such data.
Hassan Eid Elghaly   +2 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Parametrizing the exoplanet eccentricity distribution with the Beta distribution [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society: Letters, 2013
Abstract It is suggested that the distribution of orbital eccentricities for extrasolar planets is well described by the Beta distribution. Several properties of the Beta distribution make it a powerful tool for this purpose. For example, the Beta distribution can reproduce a diverse range of probability density functions (PDFs) using ...
openaire   +3 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

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